Results 81 to 90 of about 8,460,931 (324)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2000 Dementia with Lewy bodies (DLB), the second most frequent cause of primary degenerative dementias following Alzheimer's disease, has been increasingly recognized since the proposal of the consensus name and clinical diagnostic criteria. Although DLB overlaps in clinical, pathological, and genetic features with Alzheimer's disease and Parkinson's ...
openaire +3 more sources
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
Hans Lewy Interview October 7, 1981
, 1981 NOTE: to view these items please visit http://dynkincollection.library.cornell.eduInterview conducted by Eugene Dynkin with Hans Lewy on October 7, 1981 at the University of Minnesota, Minneapolis Minnesota.
Lewy, Hans
core +6 more sources
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
Acta Neuropathologica Communications, 2019 Lewy body diseases are neurodegenerative disorders characterized by Lewy bodies in the brain. Lewy body dementia (LBD) refers to two forms of Lewy body disease: Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB).
Benjamin R. Smith +6 more
doaj +1 more source
Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome
Biology Open, 2020 Protein aggregates are the pathogenic hallmarks of many different neurodegenerative diseases and include the accumulation of α-synuclein, the main component of Lewy bodies found in Parkinson's disease.
Anila Iqbal +4 more
doaj +1 more source
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile +70 more
core +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Biomolecules, 2020 The aggregation of α-synuclein (α-Syn) is a characteristic of Parkinson’s disease (PD). α-Syn oligomerization/aggregation is accelerated by the serine peptidase, prolyl oligopeptidase (POP).
Gabriel S. Santos +4 more
doaj +1 more source
The (ANTI)psychotic paradox: Lewy body dementia
European Psychiatry, 2021 Introduction Lewy Bodie Dementia (LBD) is the second more common progressive dementia caused by the deposition of proteins at the neocortical level, producing motor and psychotic symptoms (parkinsonism and visual hallucinations) which typically get ...
J. Galvañ, I. Angélico
doaj +1 more source