Results 161 to 170 of about 56,147 (276)

Associations of living alone and loneliness with neuropsychiatric symptoms in individuals with mild cognitive impairment: A retrospective cross‐sectional study

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim Living alone and loneliness are recognized risk factors for neuropsychiatric symptoms in older adults. However, the distinct of the objective condition of living alone and subjective loneliness on specific neuropsychiatric symptoms in individuals with mild cognitive impairment (MCI) remains unclear.
Kayo Takeda, Hideki Kanemoto, Takashi Suehiro, Yuto Satake, Daiki Taomoto, Shigeki Katakami, Kenji Yoshiyama, Manabu Ikeda   +7 more
wiley   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, Volume 36, Issue 2, March 2026.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, Volume 36, Issue 2, March 2026.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Longitudinal Alzheimer’s Disease Progression Modelling via Hybrid Vision Transformers and Recurrent Neural Networks With Cross‐Modal Feature Fusion

Expert Systems, Volume 43, Issue 3, March 2026.
ABSTRACT Modelling the evolution of Alzheimer's disease (AD) requires a thorough spatiotemporal study of longitudinal neuroimaging data. We propose in this paper a novel deep learning framework that uses a parallel combination of Recurrent Neural Networks (RNNs) and Vision Transformers (ViT) to extract temporal disease dynamics and spatial structural ...
Sahbi Bahroun, Gwanggil Jeon
wiley   +1 more source

Development of the Japanese Version of the Brief Dimensional Apathy Scale (b‐J‐DAS): Multidimensional Apathy in Dementia

Psychogeriatrics, Volume 26, Issue 2, March 2026.
ABSTRACT Background Apathy is a common symptom in degenerative diseases such as dementia. In this study, we developed the Japanese version of the brief Dimensional Apathy Scale (b‐J‐DAS), which requires caregivers to rate patient apathy using three apathy sub‐scales: executive, emotional and initiation.
Yuka Hirayama, Minoru Takebayashi, Ryuji Fukuhara, Toshikazu Kawagoe   +3 more
wiley   +1 more source

Depression preceding and following the diagnosis of Parkinson's disease and Lewy body dementia. [PDF]

Gen Psychiatr
Rohde C, Langeskov-Christensen M, Jørgensen LB, Borghammer P, Østergaard SD.   +4 more
europepmc   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 332-342, February 2026.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava, Lydia Herrmann, Eden Ozkan, Abhiram Kunamneni, Vinamra Swaroop, Geetika Nehra, Rohit Srivastava, Pratima Tripathi, Ken Inoki, Julie E. Goodwin   +9 more
wiley   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, Volume 13, Issue 7, 3 February 2026.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

Exposure to lead and incidence of Alzheimer's disease and all‐cause dementia in the United States

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Growing evidence suggests lead exposure may increase dementia risk, but evidence from human studies is limited. We investigated prospective associations between lead exposure and incident Alzheimer's disease (AD) and all‐cause dementia in nationally‐representative US populations.
Xin Wang, Kelly M. Bakulski, Erika Walker, Bhramar Mukherjee, Hiroko Dodge, Roger L. Albin, Henry L. Paulson, Sung Kyun Park   +7 more
wiley   +1 more source