Results 171 to 180 of about 32,200 (252)

Hippocampal GFAP in aging: Associations with AD and LATE‐NC pathologies and cognitive decline in older adults

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker for Alzheimer's disease (AD) progression in clinical studies, yet the role of brain GFAP in AD/AD‐related dementias (ADRD) pathologies and cognitive decline remains unclear. METHODS GFAP burden from CA1‐subiculum of the hippocampus were quantified.
Sonal Agrawal, Lei Yu, Sue E. Leurgans, Jialiang Li, Alifiya Kapasi, Puja Agarwal, Jeffrey L. Dage, Lisa L. Barnes, David A. Bennett, Patricia Boyle, Julie A. Schneider   +10 more
wiley   +1 more source

α-Synuclein seed amplification assay in Lewy body dementia versus Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
McWilliam OH, Bsoul R, Lund EL, Waldemar G, Hasselbalch SG, Simonsen AH, Bruun M, von Buchwald C, Aanæs K, Pedersen CK, Andersen ISB, Bech M, Areškevičiūtė A, Frederiksen KS.   +13 more
europepmc   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, Volume 99, Issue 6, Page 1405-1414, June 2026.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Risk factors and predictors for Lewy body dementia: a systematic review. [PDF]

NPJ Dement
Ratnavel A, Dino FR, Jiang C, Azmy S, Wyman-Chick KA, Bayram E.   +5 more
europepmc   +1 more source

Association between Plasma P‐tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease

Annals of Neurology, Volume 99, Issue 6, Page 1428-1437, June 2026.
Objective Clinically relevant Alzheimer's disease co‐pathology is common in Lewy body disorders. Plasma P‐tau217 is a sensitive biomarker for amyloid and tau pathology in Alzheimer's disease. The objective was to determine if plasma P‐tau217 associates with Alzheimer's disease co‐pathology and cognition in Lewy body disorders. Methods Participants had (
Thomas F. Tropea, Patricia Aldea Stevenson, Matthew Flitter, David Meehan, Amanda Morris, Ming Lu, Leonardo Iaccarino, Emily C. Collins, Michael E. Hodsdon, David Irwin, Meredith Spindler, Andres Deik, Nabila Dahodwala, Katheryn A.Q. Cousins, David A. Wolk, Leslie Shaw, Daniel Weintraub, Edward B. Lee, Alice Chen‐Plotkin, Mark Mintun, Andrew Siderowf   +20 more
wiley   +1 more source

The prevalence of apathy in Lewy body dementia: A systematic review and meta-analysis. [PDF]

Alzheimers Dement
Yu JJ, Chin KS, Loveland PM, Churilov L, Loi SM, Yassi N, Watson R.   +6 more
europepmc   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, Volume 99, Issue 6, Page 1415-1427, June 2026.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Genetic factors and comorbid pathologies interact to drive regional mitophagy alterations in Lewy body dementia. [PDF]

Acta Neuropathol
Hou X, Richardson T, Heckman MG, Fiesel FC, White LJ, Koga S, Ross OA, Dickson DW, Springer W.   +8 more
europepmc   +1 more source