Results 21 to 30 of about 56,147 (276)

Dementia with Lewy bodies

The Lancet, 2003
The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry and genetics. Dementia with Lewy bodies (DLB) is a primary, neurodegenerative dementia sharing clinical and pathological characteristics with both Parkinson's ...
McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT   +10 more
  +9 more sources

Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
The regulatory path for drug approval is increasingly well defined. Drugs for the treatment of Alzheimer disease (AD) need to show statistically significant benefit over placebo with respect to cognitive and functional measures, with the Clinical ...
Marwan N. Sabbagh, Angela Taylor, Douglas Galasko, James E. Galvin, Jennifer G. Goldman, James B. Leverenz, Kathleen L. Poston, Bradley F. Boeve, David J. Irwin, Joseph F. Quinn   +9 more
doaj   +1 more source

Dementia with Lewy bodies [PDF]

Clinical Medicine, 2019
Editor – I read with interest the ‘Acute presentation of dementia with Lewy bodies’ by Akintade and Pierres in the July edition of Clinical Medicine. [1][1] In my own practice I have seen a similar case. A diagnosis of dementia with Lewy bodies (DLB) was suspected based on clinical history,
openaire   +5 more sources

Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. [PDF]

, 2015
OBJECTIVE: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia.
Cambridge, Victoria, Lafortune, Louise, Mak, Elijah, Mason, James, McKeith, Ian, Mioshi, Eneida, O'Brien, John T, Stinton, Chris, Taylor, John-Paul, Thomas, Alan   +9 more
core   +2 more sources

The Alzheimer variant of Lewy body disease: A pathologically confirmed case-control study [PDF]

, 2005
The objective of the study was to identify clinical features that distinguish patients with dementia with Lewy bodies (DLB), who were classified as Alzheimer's disease ( AD) patients, from patients with AD.
Busch, R., Förstl, Hans, Kretzschmar, H., Kurz, A., Mösch, D., Müller, U., Neumann, M., Perneczky, R.   +7 more
core   +1 more source

Neuroinflammation in Lewy body dementia. [PDF]

, 2015
Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role.
O'Brien, John T, Rowe, James B, Surendranathan, Ajenthan   +2 more
core   +2 more sources

A new visual rating scale for Ioflupane imaging in Lewy body disease

NeuroImage: Clinical, 2018
Background: Dopaminergic loss on 123I-Ioflupane brain imaging is a recognised biomarker for dementia with Lewy bodies. It is usually assessed using a visual rating scale developed for Parkinson's disease, which may not be optimal for dementia with Lewy ...
Jim J. Lloyd, George Petrides, Paul C. Donaghy, Sean J. Colloby, Johannes Attems, John T. O'Brien, Gemma Roberts, Alan J. Thomas   +7 more
doaj   +1 more source

Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease. [PDF]

, 2015
Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive ...
Alan J. Thomas, Alexopoulos, Alison Killen, Ashburner, Baddeley, Ballard, Bentley, Bentley, Benton, Binder, Binder, Binnewijzend, Blanc, Bokde, Bosboom, Broks, Bronnick, Browndyke, Buckner, Buckner, Calderon, Celone, Corbetta, Cummings, Dam, David J. Burn, Delli Pizzi, Dosenbach, Downar, Downar, Emre, Fan, Fan, Ferman, Ferman, Fernandez-Duque, Fernández, Festa-Martino, Franciotti, Fuentes, Galvoa-Carmona, George Cherry, Gratwicke, Greicius, Hafkemeijer, Helmich, John T. O'Brien, John-Paul Taylor, Kehagia, Kenny, Kertzman, Kikuchi, Kincade, Lee, Leech, Liu, Lustig, MacDonald, MacLeod, Madhyastha, Mak, McGuiness, McKeith, McKeith, McKhann, Meppelink, Metzler-Baddeley, Michael Firbank, Molloy, Mosimann, Noe, Peraza, Peter Gallagher, Petrou, Pihlajamaki, Posner, Raichle, Rinne, Risacher, Rombouts, Rombouts, Sauer, Shine, Shulman, Sidlauskaite, Singh, Sperling, Sperling, Tales, Tales, Taylor, Thiel, Tsuboi, Vann Jones, Walker, Wang, Weinbach, Weissman, Wylie, Xenia Kobeleva, Zheng, Zhong   +101 more
core   +1 more source

Lewy Body Dementias [PDF]

Continuum, 2016
This article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), together known as the Lewy body dementias.DLB and PDD are common, clinically similar syndromes that share characteristic neuropathologic changes, including ...
openaire   +2 more sources

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Al-Sarraj, Safa, Alafuzoff, Irina, Arzberger, Thomas, Bogdanovic, Nenad, Budka, Herbert, Capellari, Sabina, Ferrer, Isidro, Gelpi, Ellen, Kovacs, Gabor G., Kovari, Viktor, Kretzschmar, Hans, Nagy, Zoltan, Parchi, Piero, Seilhean, Danielle, Soininen, Hilkka, Troakes, Claire   +15 more
core   +1 more source