Results 31 to 40 of about 32,258 (154)

Improving the identification of dementia with Lewy bodies in the context of an Alzheimer’s-type dementia

Alzheimer’s Research & Therapy, 2018
Background Dementia due to Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the two most common neurodegenerative causes of dementia. They commonly occur together, especially in older people, but clinical identification of these diseases ...
Alan J. Thomas, Fariba Mahin-Babaei, Mohammad Saidi, Debbie Lett, John Paul Taylor, Lauren Walker, Johannes Attems   +6 more
doaj   +1 more source

Dementia with Lewy Bodies.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2000
Dementia with Lewy bodies (DLB), the second most frequent cause of primary degenerative dementias following Alzheimer's disease, has been increasingly recognized since the proposal of the consensus name and clinical diagnostic criteria. Although DLB overlaps in clinical, pathological, and genetic features with Alzheimer's disease and Parkinson's ...
openaire   +3 more sources

Prodromal dementia with Lewy bodies [PDF]

Psychological Medicine, 2014
BackgroundThe clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This
P C, Donaghy, J T, O'Brien, A J, Thomas
openaire   +2 more sources

Inflammation in dementia with Lewy bodies

Neurobiology of Disease, 2022
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral inflammation in midlife increases the risk of late-onset AD, and data supporting inflammation being ...
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas   +11 more
openaire   +3 more sources

Promoting independence in Lewy body dementia through exercise (PRIDE) study: Protocol for a pilot study

Contemporary Clinical Trials Communications, 2019
Background: Lewy Body dementia (LBD) is the second most prevalent neurodegenerative dementia. This form of dementia is notable for an aggressive disease course consisting of a combination of cognitive, Parkinsonian, affective, and physiological symptoms ...
Michael Inskip, Yorgi Mavros, Perminder S. Sachdev, Maria A. Fiatarone Singh   +3 more
doaj   +1 more source

Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials

Alzheimer’s Research & Therapy, 2020
Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson’s disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society.
Jennifer G. Goldman, Leah K. Forsberg, Bradley F. Boeve, Melissa J. Armstrong, David J. Irwin, Tanis J. Ferman, Doug Galasko, James E. Galvin, Daniel Kaufer, James Leverenz, Carol F. Lippa, Karen Marder, Victor Abler, Kevin Biglan, Michael Irizarry, Bill Keller, Leanne Munsie, Masaki Nakagawa, Angela Taylor, Todd Graham   +19 more
doaj   +1 more source

Dementia With Lewy Bodies: A Review of Disease-Modifying Therapies for α-Synucleinopathies

BJPsych Open
Aims: The global demographic transition has led to a growing ageing population. Neurodegenerative disease prevalence is high in the elderly, as aged brains accumulate molecular and cellular damage.
Arzoo Dar, Sharmi Bhattacharyya
doaj   +1 more source

Lewy Body Dementias [PDF]

Continuum, 2016
This article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), together known as the Lewy body dementias.DLB and PDD are common, clinically similar syndromes that share characteristic neuropathologic changes, including ...
openaire   +2 more sources

Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology

Biology of Sex Differences
Background Lewy body dementia (LBD) phenotype is associated with the presence and degree of Lewy body, Alzheimer’s pathologies, and substantia nigra neuron loss.
Ece Bayram, David G. Coughlin, Ravi Rajmohan, Irene Litvan   +3 more
doaj   +1 more source

Clinical prevalence of Lewy body dementia

Alzheimer’s Research & Therapy, 2018
Background The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly.
Joseph P. M. Kane, Ajenthan Surendranathan, Allison Bentley, Sally A. H. Barker, John-Paul Taylor, Alan J. Thomas, Louise M. Allan, Richard J. McNally, Peter W. James, Ian G. McKeith, David J. Burn, John T. O’Brien   +11 more
doaj   +1 more source