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Dementia with Lewy bodies [PDF]
Clinical Medicine, 2019 Editor – I read with interest the ‘Acute presentation of dementia with Lewy bodies’ by Akintade and Pierres in the July edition of Clinical Medicine. [1][1] In my own practice I have seen a similar case. A diagnosis of dementia with Lewy bodies (DLB) was suspected based on clinical history,
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Dementia with Lewy Bodies [PDF]
Seminars in Neurology, 2014 Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the neocortex.
Mary Catherine, Mayo, Yvette, Bordelon
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023 The regulatory path for drug approval is increasingly well defined. Drugs for the treatment of Alzheimer disease (AD) need to show statistically significant benefit over placebo with respect to cognitive and functional measures, with the Clinical ...
Marwan N. Sabbagh +9 more
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A new visual rating scale for Ioflupane imaging in Lewy body disease
NeuroImage: Clinical, 2018 Background: Dopaminergic loss on 123I-Ioflupane brain imaging is a recognised biomarker for dementia with Lewy bodies. It is usually assessed using a visual rating scale developed for Parkinson's disease, which may not be optimal for dementia with Lewy ...
Jim J. Lloyd +7 more
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A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
Acta Neuropathologica Communications, 2019 Lewy body diseases are neurodegenerative disorders characterized by Lewy bodies in the brain. Lewy body dementia (LBD) refers to two forms of Lewy body disease: Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB).
Benjamin R. Smith +6 more
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Clinicopathological Correlates of Lewy Body Disease: Fundamental Issues [PDF]
Journal of Movement Disorders, 2010 Lewy body pathology (LBP) is the pathological hallmark of Lewy body diseases, such as Parkinson’s disease and Lewy body dementia. Recent studies have shed new light on the role of LBP, the interactions of LBP with concomitant pathologies, and the ...
Tae-Beom Ahn
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Using a Non-Wearable Actigraphy in Nursing Care for Dementia With Lewy Bodies
American Journal of Alzheimer's Disease and Other Dementias, 2022 People who have dementia with Lewy bodies often have sleep disorders. We used non-wearable devices to record and categorize the sleep patterns of patients with Lewy body dementia. Individual sleep data at a dementia–care unit in Japan were recorded using
Chiaki Fukuda RN, MNS +4 more
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Neuropathology and molecular diagnosis of Synucleinopathies
Molecular Neurodegeneration, 2021 Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytoplasmic inclusions, and glial cytoplasmic ...
Shunsuke Koga +4 more
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The (ANTI)psychotic paradox: Lewy body dementia
European Psychiatry, 2021 Introduction Lewy Bodie Dementia (LBD) is the second more common progressive dementia caused by the deposition of proteins at the neocortical level, producing motor and psychotic symptoms (parkinsonism and visual hallucinations) which typically get ...
J. Galvañ, I. Angélico
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Advances in dementia with Lewy bodies [PDF]
Therapeutic Advances in Neurological Disorders, 2021 Dementia with Lewy bodies (DLB) is a clinical diagnosis representing a specific presentation of a pathological α-synucleinopathy (Lewy body disease). DLB is one entity under the broader term Lewy body dementia, which also includes Parkinson’s disease dementia. Recent advances in DLB include publication of updated diagnostic criteria and recognition of
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