Results 161 to 170 of about 72,581 (277)

Associations between apathy and global cognition in a 5‐year follow‐up of individuals with Alzheimer's disease

Journal of Neuropsychology, EarlyView.
Abstract Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) associated with cognitive and functional impairment. Longitudinal studies have examined the associations between apathy and cognition in AD and other dementias, but more information is needed to understand whether the relationships are consistent longitudinally, and ...
Henna‐Riikka Loukola, Maikki Kärkkäinen, Tuomas Selander, Kirsi Honkalampi, Anne M. Koivisto, Toni T. Saari   +5 more
wiley   +1 more source

Increased intervals in enzyme replacement therapy for stable type 1 Gaucher disease: A non‐inferiority sequential trial emulation

Journal of Internal Medicine, EarlyView.
Abstract Objective To compare the efficacy and safety of extended interval (Q3–4W) enzyme replacement therapy (ERT) versus standard biweekly (Q2W) ERT in clinically stable type 1 Gaucher disease (GD) patients. Methods We emulated a target trial with a sequential trial design, using data from the French Gaucher Disease Registry.
Maxime Beydon, Jérôme Stirnemann, Karima Yousfi, Samira Zebiche, Dalil Hamroun, Anaïs Brassier, Samia Pichard, Laure Swiader, Thierry Billette de Villemeur, Bénédicte Héron, Florence Dalbies, Bérengère Cador, Anne‐Sophie Guemann, Francis Gaches, Bénédicte Hivert, Vanessa Leguy‐Seguin, Agathe Masseau, Yves‐Marie Pers, Magali Pettazzoni, Soumeya Bekri, Catherine Caillaud, Edouard Le Guillou, Marie Szymanowski, Leonardo Astudillo, Wladimir Mauhin, Yann Nadjar, Christine Serratrice, Marc G. Berger, Fabrice Camou, Nadia Belmatoug, Yann Nguyen, the French Evaluation of Gaucher Disease Treatment Committee   +31 more
wiley   +1 more source

Association of mitochondrial genetic background with pS65-Ub in Lewy body disease. [PDF]

Acta Neuropathol
Tran NLK, Hou X, Heckman MG, Fiesel FC, Koga S, Watkins MM, Sledge HJ, Gibbs JR, Traynor BJ, Dalgard CL, Scholz SW, Dickson DW, Springer W, Ross OA.   +13 more
europepmc   +1 more source

Assessing the Adaptive/Maladaptive Strategies of Mastication in Older Taiwanese Individuals Using the Masticatory Adaptation Experience Questionnaire (MAEQ)

Journal of Oral Rehabilitation, EarlyView.
The study aims to establish the Masticatory Adaptation Experience Questionnaire (MAEQ) and investigate age‐related factors of masticatory adaptation. ABSTRACT Background There are various tests to assess the individual performance of mastication. However, it has remained unknown how individuals used adaptive (e.g., ‘increasing time to chew’) and ...
Chia‐Shu Lin, Ta‐Chung Chen, Yi‐Chen Chen, Li‐Jung Chao, Wei‐Chieh Kao, Jong‐Ling Fuh   +5 more
wiley   +1 more source

A Systematic Review and Meta‐Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition

Obesity Reviews, EarlyView.
ABSTRACT Background In 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
Amene Saghazadeh, Mahsa Dolatshahi, Soheil Mohammadi, Sara Hosseinzadeh Kassani, Mahshid Naghashzadeh, Joseph E. Ippolito, Claude B. Sirlin, Bettina Mittendorfer, Matthew R. Brier, Suzanne E. Schindler, John C. Morris, Danny Mou, Hani Charles Soudah, Tammie L. S. Benzinger, Cyrus A. Raji   +14 more
wiley   +1 more source

Talking therapies for anxiety and depression in people affected by dementia: A scoping meta‐review

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Background Symptoms of anxiety and depression are common in people affected by dementia (people with dementia and family carers). There are many reviews of psychological interventions to reduce stress and distress in people with dementia and family carers, but little cross‐fertilisation with the evidence base underpinning NHS Talking Therapies
Georgina Charlesworth, Cassie Eastham, Lydia Morris   +2 more
wiley   +1 more source

Multicenter development and validation of a probability-based model to diagnose Lewy body disease using ¹²³I-meta-iodobenzylguanidine. [PDF]

Eur J Nucl Med Mol Imaging
Nakajima K, Komatsu J, Matsumura T, Orimo S, Yoshita M, Frantellizzi V, De Feo MS, Greenfinch G, Thomas A, Assante R, Acampa W, Shirasaki N, Yokoyama K, Wakabayashi H, Noguchi-Shinohara M, Ono K, Kinuya S.   +16 more
europepmc   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Disturbing dreams and dementia incidence across diverse cohort studies: A COSMIC collaboration study

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Distressing dreams were previously reported to predict future all‐cause dementia among predominantly white US participants aged 79–89 years, particularly in men. We investigated whether disturbing dreams (nightmares and bad dreams) were associated with all‐cause and Alzheimer dementia (AD) among individuals aged 60–89 years from diverse ...
Darren M. Lipnicki, Ashleigh S. Vella, Erico Castro‐Costa, Sergio Luis Blay, Maria Fernanda Lima‐Costa, Karen Ritchie, Elena Rolandi, Annalisa Davin, Michele Rossi, Ki Woong Kim, Ji Won Han, Dae Jong Oh, Ding Ding, Qianhua Zhao, Xiaowen Zhou, Yen‐Ching Chen, Jen‐Hau Chen, Perminder S. Sachdev, for Cohort Studies of Memory in an International Consortium (COSMIC)   +18 more
wiley   +1 more source

Idiopathic polyneuropathy with neurogenic autonomic failure - an early manifestation of Lewy body disease? a case report. [PDF]

BMC Neurol
Andersen NH, Borghammer P, Doppler K, Gottrup H, Knudsen K, Kuzkina A, Van Den Berge N, Otto M, Terkelsen AJ.   +8 more
europepmc   +1 more source