Results 191 to 200 of about 72,473 (300)

Late-Onset Oral Cenesthopathy With Dopaminergic Dysfunction: Therapeutic Response to Pramipexole in a Case With Suspected Prodromal Lewy Body Disease. [PDF]

Psychogeriatrics
Matsui H, Tamura T, Kameyama M, Omori Y, Sugihara G, Takeuchi T, Takahashi H, Furuta K.   +7 more
europepmc   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, Volume 36, Issue 2, March 2026.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Longitudinal Alzheimer’s Disease Progression Modelling via Hybrid Vision Transformers and Recurrent Neural Networks With Cross‐Modal Feature Fusion

Expert Systems, Volume 43, Issue 3, March 2026.
ABSTRACT Modelling the evolution of Alzheimer's disease (AD) requires a thorough spatiotemporal study of longitudinal neuroimaging data. We propose in this paper a novel deep learning framework that uses a parallel combination of Recurrent Neural Networks (RNNs) and Vision Transformers (ViT) to extract temporal disease dynamics and spatial structural ...
Sahbi Bahroun, Gwanggil Jeon
wiley   +1 more source

Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology Study. [PDF]

Mov Disord
Diaz-Galvan P, Przybelski SA, Lesnick TG, Murray ME, Nguyen A, Reichard RR, Dickson DW, Ono D, Senjem ML, Schwarz CG, Gunter J, Lowe V, Forsberg LK, Fields JA, Savica R, Graff-Radford J, Ramanan VK, Jones D, Botha H, St Louis EK, Knopman D, Day GS, Graff-Radford N, Kremers W, Petersen RC, Jack CR, Ferman TJ, Boeve BF, Kantarci K.   +28 more
europepmc   +1 more source

Development of the Japanese Version of the Brief Dimensional Apathy Scale (b‐J‐DAS): Multidimensional Apathy in Dementia

Psychogeriatrics, Volume 26, Issue 2, March 2026.
ABSTRACT Background Apathy is a common symptom in degenerative diseases such as dementia. In this study, we developed the Japanese version of the brief Dimensional Apathy Scale (b‐J‐DAS), which requires caregivers to rate patient apathy using three apathy sub‐scales: executive, emotional and initiation.
Yuka Hirayama, Minoru Takebayashi, Ryuji Fukuhara, Toshikazu Kawagoe   +3 more
wiley   +1 more source

Alpha-synuclein seed amplification assay longitudinal outcomes in Lewy body disease spectrum. [PDF]

Brain
Mastrangelo A, Mammana A, Hall S, Stomrud E, Zenesini C, Rossi M, Janelidze S, Ticca A, Palmqvist S, Magliocchetti F, Baiardi S, Mattsson-Carlgren N, Hansson O, Parchi P.   +13 more
europepmc   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 332-342, February 2026.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava, Lydia Herrmann, Eden Ozkan, Abhiram Kunamneni, Vinamra Swaroop, Geetika Nehra, Rohit Srivastava, Pratima Tripathi, Ken Inoki, Julie E. Goodwin   +9 more
wiley   +1 more source

Genome-wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease. [PDF]

Alzheimers Dement
Hou X, Heckman MG, Fiesel FC, Koga S, Soto-Beasley AI, Watzlawik JO, Zhao J, Valentino RR, Johnson PW, White LJ, Quicksall ZS, Reddy JS, Bras J, Guerreiro R, Zhao N, Bu G, Dickson DW, Ross OA, Springer W.   +18 more
europepmc   +1 more source