Results 211 to 220 of about 72,473 (300)

A sensitive assay reveals structural requirements for α-synuclein fibril growth [PDF]

, 2017
Bagchi, Devika P, Dhavale, Dhruva D, Engel, Laura A, Kotzbauer, Paul T, Sarezky, Jonathan, Tsai, Christina   +5 more
core   +2 more sources

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS Baseline data from a multicenter cohort were analyzed.
Anqi Cheng, Yinxi Zou, Linwen Liu, Hebo Wang, Zhibing Ai, Shiwen Wu, Qianqian Si, Yiyang Liu, Huanyu Zhou, Haoyao Guo, Qiuyu Yu, Zijue Wang, Mingli Li, Caiyan Liu, Weihai Xu   +14 more
wiley   +1 more source

Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.
Chao Tang, Jiaxin Yang, Xiaoyang Lei, Ming Zhang, Yi Chen, Xiaoxue Peng, Dian He   +6 more
wiley   +1 more source

Greater locus coeruleus vulnerability in atypical clinicopathologic forms of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The locus coeruleus (LC) degenerates early in Alzheimer's disease (AD). However, the extent of rostrocaudal degeneration across clinicopathologic heterogeneity remains underexplored in AD. METHODS Using digital pathology, we quantified LC neuronal density and area at three neuroanatomic levels in a large AD series.
Sara Rose Dunlop, Billie J. Matchett, Alexander F. Mannsbart, Fadi S. Hanna Al‐Shaikh, Zhongwei Peng, Darren M. Rothberg, Jessica F. Tranovich, Ranjan Duara, Idaly Velez Uribe, Joselen Gondrez, Rickey E. Carter, Tanis J. Ferman, Gregory S. Day, Neill R. Graff‐Radford, Dennis W. Dickson, Lea T. Grinberg, Melissa E. Murray   +16 more
wiley   +1 more source

Distinct transcriptional alterations distinguish Lewy body disease from Alzheimer's disease. [PDF]

Brain
Olney KC, Rabichow BE, Wojtas AM, DeTure M, McLean PJ, Dickson DW, Chang R, Ross OA, Fryer JD.   +8 more
europepmc   +1 more source

High vulnerability of medial prefrontal pyramidal neurons in post‐stroke, vascular, Alzheimer's disease, and aging‐related dementias

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The medial prefrontal cortex (mPFC) is critical for executive function, behavioral inhibition, and memory. Its high vulnerability to dementia, compared to other prefrontal regions, remains unclear. METHODS We analyzed post mortem brain tissue from 118 older subjects, including post‐stroke survivors, Alzheimer's disease; vascular ...
Dan D. Jobson, Yoshiki Hase, Lauren Walker, Tuomo Polvikoski, Ahmad A. Khundakar, Louise Allan, Raj N. Kalaria   +6 more
wiley   +1 more source

Association of Alzheimer's and Lewy body disease pathology with basal forebrain volume and cognitive impairment. [PDF]

Alzheimers Res Ther
Schumacher J, Teipel S, Storch A.
europepmc   +1 more source

Urinary tract infection‐related delirium in Alzheimer's disease and related dementias: Clinical challenges and translational opportunities

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease and related dementias (ADRD) affects millions of patients worldwide and is a leading cause of morbidity in older adults. Patients with ADRD are particularly susceptible to developing urinary tract infection (UTI) and UTI‐related delirium, creating a self‐perpetuating cycle in which ADRD increases vulnerability to infection ...
Sarah Kim, Sarah Kremen, Itai Danovitch, Shouri Lahiri   +3 more
wiley   +1 more source

Distinct subcellular localization of tau and alpha-synuclein in lewy body disease. [PDF]

Acta Neuropathol Commun
Fischer DL, Menard M, Abdelaziz OZ, Kanaan NM, Cobbs VG, Kennedy RE, Serrano GE, Beach TG, Volpicelli-Daley LA.   +8 more
europepmc   +1 more source