Results 251 to 260 of about 72,473 (300)
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Southern Medical Journal, 1996
Lewy bodies have historically been considered a histopathologic hallmark of idiopathic Parkinson's disease. Recently, it has become clear that Lewy bodies play a role in neurodegenerative processes other than idiopathic Parkinson's disease, including diffuse Lewy body disease and diffuse Lewy bodies with concomitant Alzheimer's disease changes.
T A, Smith, R A, Prayson
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Lewy bodies have historically been considered a histopathologic hallmark of idiopathic Parkinson's disease. Recently, it has become clear that Lewy bodies play a role in neurodegenerative processes other than idiopathic Parkinson's disease, including diffuse Lewy body disease and diffuse Lewy bodies with concomitant Alzheimer's disease changes.
T A, Smith, R A, Prayson
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Current Treatment Options in Neurology, 2001
Diffuse Lewy body disease (DLB) is a neurodegenerative disorder characterized by dementia, fluctuations in mental status, hallucinations, and parkinsonism. Diffuse Lewy body disease is the second most common cause of dementia, following Alzheimer's disease.
Theresa A., Zesiewicz +3 more
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Diffuse Lewy body disease (DLB) is a neurodegenerative disorder characterized by dementia, fluctuations in mental status, hallucinations, and parkinsonism. Diffuse Lewy body disease is the second most common cause of dementia, following Alzheimer's disease.
Theresa A., Zesiewicz +3 more
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Movement Disorders, 2006
AbstractThe clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly ...
Momjian-Mayor, Isabelle +5 more
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AbstractThe clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly ...
Momjian-Mayor, Isabelle +5 more
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Journal of Geriatric Psychiatry and Neurology, 2002
Lewy body disease includes clinically and pathologically defined disorders in which Lewy bodies occur in the nervous system. In recent years, the molecular features of these disorders have been emerging. Several genetic loci have been identified in association with familial Lewy body disease; however, the genetic risks underlying most cases of ...
Katrina, Gwinn-Hardy +1 more
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Lewy body disease includes clinically and pathologically defined disorders in which Lewy bodies occur in the nervous system. In recent years, the molecular features of these disorders have been emerging. Several genetic loci have been identified in association with familial Lewy body disease; however, the genetic risks underlying most cases of ...
Katrina, Gwinn-Hardy +1 more
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Aneuploidy in Lewy body diseases
Neurobiology of Aging, 2015An increase in DNA content is associated with neuronal degeneration in Alzheimer's disease but has not been evaluated in Lewy body diseases. Using stereological principles, flow cytometry, and standard histopathologic methods, we evaluated the number and DNA content of neurons and all cells and the severity of Lewy and Alzheimer pathologies, in brain ...
Yue Yang +2 more
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Annals of Neurology, 2006
AbstractObjectiveThe Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. Patients harboring the G2019S substitution usually present with clinical Parkinson's disease.MethodsHerein, we report that the most common neuropathology of G2019S‐associated Parkinson's disease is Lewy body disease ...
Owen A, Ross +10 more
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AbstractObjectiveThe Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. Patients harboring the G2019S substitution usually present with clinical Parkinson's disease.MethodsHerein, we report that the most common neuropathology of G2019S‐associated Parkinson's disease is Lewy body disease ...
Owen A, Ross +10 more
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The Journal of Neuropsychiatry and Clinical Neurosciences, 1998
The authors assessed the accuracy of published clinical criteria and their own modifications of those criteria in diagnosing Lewy body disease (LBD). Clinical diagnoses were made by two clinicians, blinded to neuropathologic diagnoses, using the Rochester Alzheimer's Disease Center database and traditional medical records.
M, Papka +3 more
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The authors assessed the accuracy of published clinical criteria and their own modifications of those criteria in diagnosing Lewy body disease (LBD). Clinical diagnoses were made by two clinicians, blinded to neuropathologic diagnoses, using the Rochester Alzheimer's Disease Center database and traditional medical records.
M, Papka +3 more
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Parkinson's Disease Dementia and Lewy Body Disease
Seminars in Neurology, 2019AbstractDementia with Lewy bodies (DLB) and Parkinson's disease dementia (PD-D) are Lewy body-related neurodegenerative disorders sharing common clinical and neuropathological findings. The clinical features of both conditions include cognitive impairment, behavioral symptoms, autonomic dysfunction, sleep disorders, and parkinsonism.
Mine, Sezgin +3 more
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2003
Our understanding of the clinical and pathological features of dementia in late life is changing. Indeed, the way we conceptualize, investigate, and manage dementia has altered radically over recent times. An increasing public awareness, coupled with greater expectations, changing demography, and an ever more productive research alliance among ...
Robert Barber +2 more
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Our understanding of the clinical and pathological features of dementia in late life is changing. Indeed, the way we conceptualize, investigate, and manage dementia has altered radically over recent times. An increasing public awareness, coupled with greater expectations, changing demography, and an ever more productive research alliance among ...
Robert Barber +2 more
openaire +1 more source