Results 1 to 10 of about 11,952,418 (234)

Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone

Frontiers in Endocrinology, 2023
IntroductionAge-related decline in testosterone is associated with Leydig cell aging with impaired testosterone synthesis in aging. Obesity accelerates the age-related decline in testosterone.
Dandan Luo, Dandan Luo, Xiangyu Qi, Xiaoqin Xu, Xiaoqin Xu, Leilei Yang, Leilei Yang, Chunxiao Yu, Chunxiao Yu, Qingbo Guan, Qingbo Guan   +10 more
doaj   +2 more sources

Stimulation of TM3 Leydig cell proliferation via GABA_A receptors: A new role for testicular GABA [PDF]

Reproductive Biology and Endocrinology, 2004
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB ...
Krieger Annette, Thalhammer Andrea, Doepner Richard FG, Geigerseder Christof, Mayerhofer Artur   +4 more
doaj   +2 more sources

Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits [PDF]

Brazilian Journal of Medical and Biological Research, 2002
Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and ...
A.C.S. Castro, W.E. Berndtson, F.M. Cardoso   +2 more
doaj   +3 more sources

A Short-Term Exposure to Tributyltin Blocks Leydig Cell Regeneration in the Adult Rat Testis

Frontiers in Pharmacology, 2017
Background: Tributyltin (TBT) is widely used as an antifouling agent that may cause reproductive toxicity. The mechanism of TBT on Leydig cell development is still unknown. The objective of the present study was to investigate whether a brief exposure to
Xiaolong Wu, Jianpeng Liu, Yue Duan, Shiyu Gao, Yao Lü, Xiaoheng Li, Qiqi Zhu, Xianwu Chen, Jing Lin, Leping Ye, Ren-Shan Ge, Ren-Shan Ge   +11 more
doaj   +2 more sources

Insulin-like factor 3 (INSL3) and the HPG axis in the male [PDF]

Frontiers in Endocrinology, 2014
The HPG (hypothalamo-pituitary-gonadal) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation.
Richard eIvell, Richard eIvell, Kee eHeng, Ravinder eAnand-Ivell   +3 more
doaj   +5 more sources

A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis

Scientific Reports, 2017
Cadmium is an endocrine disruptor, impairing male reproduction. The objective of this study is to investigate whether cadmium affects rat Leydig cell regeneration and to dissect the underlying mechanism.
Xiaolong Wu, Xiaoling Guo, Huang Wang, Songyi Zhou, Lili Li, Xiaomin Chen, Guimin Wang, Jianpeng Liu, Hong-Shan Ge, Ren-Shan Ge   +9 more
doaj   +2 more sources

Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells. [PDF]

PLoS ONE, 2013
Development of the testis begins with the expression of the SRY gene in pre-Sertoli cells. Soon after, testis cords containing Sertoli and germ cells are formed and fetal Leydig cells subsequently develop in the interstitial space. Studies using knockout
Kanako Miyabayashi, Yuko Katoh-Fukui, Hidesato Ogawa, Takashi Baba, Yuichi Shima, Noriyuki Sugiyama, Kunio Kitamura, Ken-ichirou Morohashi   +7 more
doaj   +2 more sources

Leydig cell aging and hypogonadism [PDF]

Experimental Gerontology, 2015
Leydig cell testosterone (T) production is reduced with age, resulting in reduced serum T levels (hypogonadism). A number of cellular changes have been identified in the steroidogenic pathway of aged Leydig cells that are associated with reduced T formation, including reductions in luteinizing hormone (LH)-stimulated cAMP production, the cholesterol ...
M C, Beattie, L, Adekola, V, Papadopoulos, H, Chen, B R, Zirkin   +4 more
openaire   +3 more sources

When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk [PDF]

Cells
Declining Leydig cell steroidogenesis contributes to late-onset hypogonadism and to age-associated impairment of male reproductive health. Determinants of dysfunction extend beyond chronological aging.
Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Sotirios Koukos, Michael Chrisofos, Nikolaos Sofikitis   +5 more
doaj   +2 more sources

In Vitro analysis of the effect of mono-(2-ethylhexyl) phthalate (MEHP) exposure on macrophage inflammatory responses in relationship to Leydig cell steroid production [PDF]

Frontiers in Toxicology
Macrophages, essential components of the innate immune system, are considered to be involved in the regulation of Leydig cell steroidogenesis, though by mechanisms that remain uncertain.
Akhil Adla, Allison Lunney, Barry Zirkin, Kassim Traore   +3 more
doaj   +2 more sources