Results 21 to 30 of about 11,952,476 (292)
Clinical Pediatric Hematology-Oncology, 2022 Leydig cell tumors can cause precocious puberty in prepubertal males. Radical orchiectomy is the standard therapy for Leydig cell tumors, with a good overall prognosis.
Jeong Ho Ahn +3 more
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Leydig cells express neural cell adhesion molecules in vivo and in vitro [PDF]
, 1992 The neural cell adhesion molecule (NCAM) polypeptides are expressed by numerous tissues during embryonic development, where they are involved in cell-cell interactions.
Barthels, D. +7 more
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Parathyroid Hormone-Related Protein Promotes Rat Stem Leydig Cell Differentiation
Frontiers in Physiology, 2017 The regulatory factors for stem Leydig cell development are largely unknown. Herein, we reported that parathyroid hormone-related protein (PTHrP) may be a factor to regulate this process.
Tiantian Song +11 more
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Reproductive Biology and Endocrinology, 2021 Background Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a crucial role in various human diseases,
Xu Zhou +6 more
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Novas perspectivas no diagnóstico do hipogonadismo pediátrico masculino: a importância do AMH como marcador de células de Sertoli [PDF]
, 2011 Sertoli cells are the most active cell population in the testis during infancy and childhood. In these periods of life, hypogonadism can only be evidenced without stimulation tests, if Sertoli cell function is assessed.
Grinspon, Romina, Rey, Rodolfo Alberto
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Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro
BMC Pharmacology and Toxicology, 2019 Background It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell function, their roles in Leydig cell ...
Jingwei Zhang +8 more
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Insights into GABA receptor signalling in TM3 Leydig cells [PDF]
, 2005 gamma-Aminobutyric acid (GABA) is an emerging signalling molecule in endocrine organs, since it is produced by endocrine cells and acts via GABA(A) receptors in a paracrine/autocrine fashion.
Artur Mayerhofer +28 more
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Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1
Frontiers in Endocrinology, 2018 Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly involved in rodents. It is essential for sperm production.
Yan Yang +13 more
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Ecotoxicology and Environmental Safety, 2021 Perfluorooctane sulfonate is related to male reproductive dysfunction in rats and humans. However, the underlying mechanism remains unknown. Here, we reported the effects of short-term exposure to perfluorooctane sulfonate on the regeneration of Leydig ...
Baiping Mao +7 more
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Long-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging [PDF]
Proceedings of the National Academy of Sciences, 1999 Male aging is accompanied by reduced testosterone production by the Leydig cells, the testosterone-producing cells of the testis. The mechanism by which this occurs is unknown. Based on the observations that reactive oxygen is capable of damaging components of the steroidogenic pathway and that reactive oxygen is produced during steroidogenesis itself,
H, Chen, B R, Zirkin
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