Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui+15 more
wiley +1 more source
O USO DO SERRA GERAL NO ESTADO DO MATO GROSSO DO SUL
O Estado de Mato Grosso do Sul é rico tanto em recursos hídricos superficiais quanto em subterrâneos. A captação de águas subterrâneas se mostrou crescente nas últimas décadas, chegando a ser superior a água superficial.
Caroline Aparecida de Almeida Silva+1 more
doaj
Protein O‐glycosylation in the Bacteroidota phylum
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns+2 more
wiley +1 more source
The Effect of Oral Feeding of Tribulus terrestris L. on Sex Hormone and Gonadotropin Levels in Addicted Male Rats [PDF]
Background: Opioids can exert adverse effects on the body. Morphine, an opioid drug, reduces hormone levels and fertility, and causes sexual activity disorders.
Mohammad Hassan Ghosian Moghaddam+3 more
doaj
Impact of resistance training and melatonin consumption on sex hormone levels, PGF2α, FSH, LH, pain intensity, and sleep quality in girls with primary dysmenorrhea [PDF]
Background and Aim: Primary dysmenorrhea significantly affects the daily lives and performance of girls. This study aimed to investigate the effects of resistance training and melatonin consumption on sex hormone levels, PGF2α, FSH, LH, pain intensity ...
Neda Kafi+3 more
doaj
In this paper, in the framework of NRQCD we study the light hadron (LH) decays of the spin-triplet (S=1) D-wave heavy quarkonia. The short distance coefficients of all Fock states in the $^3D_J(J=1,2,3)$ quarkonia including D-wave color-singlet, P-wave ...
Chao, Kuang-Ta, Fan, Ying, He, Zhi-Guo
core +1 more source
The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A+1 more
core +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji+3 more
wiley +1 more source
Paleo Festival Nyon: analyse de faisabilité pour la mise en place de vaisselle consignée et lavable [PDF]
Des sommets mondiaux sont organisés à travers la planète pour trouver des solutions contre le réchauffement climatique. Cependant, nos représentants parlent beaucoup mais n’agissent pas assez. Même à petite échelle, chaque geste est important.
Amrein, Daniel, Flückiger, Manon
core
The "ram effect": new insights into neural modulation of the gonadotropic axis by male odors and socio-sexual interactions [PDF]
Reproduction in mammals is controlled by the hypothalamo-pituitary-gonadal (HPG) axis under the influence of external and internal factors such as photoperiod, stress, nutrition, and social interactions.
Abbott+151 more
core +4 more sources