Results 31 to 40 of about 2,932,876 (332)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Special Libraries, September 1933 [PDF]

open access: yes, 1932
Volume 24, Issue 8https://scholarworks.sjsu.edu/sla_sl_1933/1007/thumbnail ...
Special Libraries Association
core   +2 more sources

Designing the Cyberinfrastructure for Spatial Data Curation, Visualization, and Sharing

open access: yesIASSIST Quarterly, 2017
Widely used across disciplines such as natural resources, social sciences, public health, humanities, and economics, spatial data is an important component in many studies and has promoted interdisciplinary research development.
Yue Li, Nicole Kong, Stanislav Pejša
doaj   +1 more source

Flipping it online: re-imagining teaching searching for knowledge syntheses

open access: yesJournal of the Canadian Health Libraries Association, 2021
Introduction: This program description outlines our approach to re-developing our 3-part series for graduate students on comprehensive searching for knowledge syntheses from in-person to online delivery using a flipped classroom model. The re-development
Kaitlin Fuller   +3 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

VLA Paraprofessional Forum 2011 Conference Report: Libraries: Paving the Way for Success

open access: yesVirginia Libraries, 2011
The nineteenth annual Virginia Library Association Paraprofessional Forum Conference was held May 22–24, 2011, at the Holiday Inn Select/Koger South Conference Center in Chesterfield County.
Virginia Libraries
doaj  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Special Libraries, February 1966 [PDF]

open access: yes, 1964
Volume 57, Issue 2https://scholarworks.sjsu.edu/sla_sl_1966/1001/thumbnail ...
Special Libraries Association
core   +4 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Special Libraries, October 1947 [PDF]

open access: yes, 1946
Volume 38, Issue 8https://scholarworks.sjsu.edu/sla_sl_1947/1007/thumbnail ...
Special Libraries Association
core   +3 more sources

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