Results 61 to 70 of about 25,503,651 (307)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
IEEE Transactions on Big DataVector databases typically manage large collections of embedding vectors. Currently, AI applications are growing rapidly, and so is the number of embeddings that need to be stored and indexed. The Faiss library is dedicated to vector similarity search, a core functionality of vector databases.
Matthijs Douze +8 more
openaire +4 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
СТАНОВЛЕНИЕ ОБРАЗОВАНИЯ В ТОМСКОЙ ГУБЕРНИИ: ИЗ АРХИВНЫХ ФОНДОВ ШКОЛЬНОГО МУЗЕЯ
Научно-педагогическое обозрение, 2020 Основная цель статьи – показать историю становления и развития начальных училищ и гимназий (мужских и женских) в сибирских территориях периода ХVII – начала ХХ в.
Ревякина Валентина Ивановна +1 more
doaj +1 more source
Libraries and the REF: how do librarians contribute to research excellence?
Insights: The UKSG Journal, 2020 Librarians support research in a wide variety of ways. However, librarians may not always receive recognition for the valuable contributions they make to the research life cycle or research environments.
Dominic Walker
doaj +1 more source
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Knjižnična građa tiskana u tiskari Franjevačkog samostana u Osijeku – začetak tiskarstva u Slavoniji
Diacovensia, 2020 Printing in Osijek began with the arrival of the Franciscans and the establishment of the first printing house in the area in 1735. The Franciscans were allowed to open a small printing house in the monastery for the needs of the province.
Marina Vinaj, Ivana Knežević Križić
doaj +1 more source
, 2018 The Library Line was a publication of the Toledo Lucas County Public Library that ran from 1993 through 2010. It covered library news, events, readers' advisory, and listed donors.
Toledo Lucas County Public Library
core