Results 61 to 70 of about 1,914,269 (259)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

СТАНОВЛЕНИЕ ОБРАЗОВАНИЯ В ТОМСКОЙ ГУБЕРНИИ: ИЗ АРХИВНЫХ ФОНДОВ ШКОЛЬНОГО МУЗЕЯ

Научно-педагогическое обозрение, 2020
Основная цель статьи – показать историю становления и развития начальных училищ и гимназий (мужских и женских) в сибирских территориях периода ХVII – начала ХХ в.
Ревякина Валентина Ивановна, Семибратов Семен Олегович   +1 more
doaj   +1 more source

Libraries and the REF: how do librarians contribute to research excellence?

Insights: The UKSG Journal, 2020
Librarians support research in a wide variety of ways. However, librarians may not always receive recognition for the valuable contributions they make to the research life cycle or research environments.
Dominic Walker
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Knjižnična građa tiskana u tiskari Franjevačkog samostana u Osijeku – začetak tiskarstva u Slavoniji

Diacovensia, 2020
Printing in Osijek began with the arrival of the Franciscans and the establishment of the first printing house in the area in 1735. The Franciscans were allowed to open a small printing house in the monastery for the needs of the province.
Marina Vinaj, Ivana Knežević Križić
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

For the Library [PDF]

Science, 1978
  +8 more sources

Use of EZProxy to access international journals among students of Library and Information Science, University of Indonesia

Record and Library Journal, 2016
Student’s magister is one of user library university of Indonesia those who need information regarding duty as carried out college.  With different backgrounds students as, made they need facilities sources of information easy and efficient.
Rusdiyah Ciptaning Dwi Kusuma
doaj   +1 more source

Digital libraries of the future – and the role of libraries

Library Hi Tech, 2006
PurposeThe purpose of this article is to introduce the digital libraries of the future, their enabling technologies and their organisational models.Design/methodology/approachThe paper first discusses the requirements for the digital libraries of the future, then presents the DILIGENT infrastructure as a technological response to these requirements and,
openaire   +3 more sources