Results 111 to 120 of about 60,981 (267)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Association of life’s essential 8 with depressive symptoms in US cardiovascular disease survivors: a cross-sectional analysis from NHANES 2007–2018

BMC Psychology
Introduction In recent years, Life’s Essential 8 (LE8) has been increasingly applied as an indicator to assess cardiovascular health condition. Depression is common in patients with cardiovascular diseases (CVD).
Dan Zhang, Xin Liu, Xiaodong Ye, Shanshan Huang, Kai Zheng, Suiqiang Zhu, Xiaoyan Liu, Guo Li   +7 more
doaj   +1 more source

Associations between Life's Essential 8 and risks of all-cause and cardiovascular mortality in cancer survivors: A prospective cohort study from NHANES

Heliyon
Background: Life's Essential 8 (LE8), an indicator of cardiovascular health (CVH), can predict overall and cardiovascular mortality in the general population. Considering that cancer survivors have a higher risk of cardiovascular disease (CVD), our study
Wen Liu, Jia Wang, Miaomiao Wang, Huimin Hou, Xin Ding, Miao Wang, Ming Liu   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Food Insecurity and Ideal Cardiovascular Health Risk Factors Among US Adolescents

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Food insecurity, a social and economic condition of limited availability of healthy food, is a risk factor for adverse cardiovascular health outcomes among adults; few studies have been conducted in adolescents.
Nour M. Hammad, Julia A. Wolfson, Sarah D. de Ferranti, Walter C. Willett, Cindy W. Leung   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

From inanimate matter to living systems [PDF]

Since the early part of this century, the Genesis account of the origin and evolution of life has been explained as an extrapolation of astronomical and geochemical processes.
Fox, S. W.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Association between cardiovascular health and overactive bladder

Scientific Reports
Life’s Essential 8 (LE8) is an emerging composite metric of cardiovascular health encompassing diet, physical activity, smoking, sleep, weight, cholesterol, blood glucose, and blood pressure.
Zehao Li, Xiangliang Liu, Yuguang Li, Xinqiao Chen, Ziming Liu, Xiaoxue Gao, Jiuwei Cui   +6 more
doaj   +1 more source

Association of Socioeconomic Status With Life's Essential 8 in the National Health and Nutrition Examination Survey: Effect Modification by Sex

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Higher scores for the American Heart Association Life's Essential 8 (LE8) metrics, blood pressure, cholesterol, glucose, body mass index, physical activity, smoking, sleep, and diet, are associated with lower risk of chronic disease ...
Amaris Williams, Timiya S. Nolan, Jacsen Luthy, LaPrincess C. Brewer, Robin Ortiz, Kartik K. Venkatesh, Eduardo Sanchez, Guy N. Brock, Saira Nawaz, Jennifer A. Garner, Daniel M. Walker, Darrell M. Gray, Joshua J. Joseph   +12 more
doaj   +1 more source