Results 121 to 130 of about 60,981 (267)

Human Capabilities and Human Authorities: A Comment on Martha Nussbaum’s Women and Human Development [PDF]

, 2003
What does it mean to be truly human? And, relatedly, what does it mean to be treated as truly human, and with dignity, by the state, or community, of which one is a part?
West, Robin
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Assessing the impact of volatile organic compounds on cardiovascular health: Insights from the National Health and Nutrition Examination Survey 2011–2020

Ecotoxicology and Environmental Safety
Volatile organic compounds (VOCs) are environmental pollutants that may negatively impact cardiovascular health. This study investigates the association between VOC mixtures, measured through urinary VOC metabolites (VOCMs), and cardiovascular health ...
Lina Wang, Jianqiang Du, Xiaoming Wu, Zhenhai Gan   +3 more
doaj   +1 more source

The Importance of Character Education for Tweens as Consumers [PDF]

Tweens is a term that denotes a market segment mentality that falls between children at the lower end and teens at the upper end. Tweens marketing strategies are considered critical for most global brands.
Ahmed Taher, Ehab M. Abou Aish, Noha El-Bassiouny   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Her Choice, Her Problem: How Having a Choice Can Diminish Family Solidarity [PDF]

, 2011
This Article explores a little-noticed dimension of abortion and assisted suicide (or voluntary euthanasia): how choosing to reject those options can have a negative impact on the legally authorized choosers.
Stith, Richard
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Life's Essential 8 (LE8) is an enhanced metric for cardiovascular health. The interrelations among LE8, biomarkers of aging, and disease risks are unclear.
Madeleine Carbonneau, Yi Li, Brenton Prescott, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Joanne M. Murabito, Nancy L. Heard‐Costa, Vanessa Xanthakis, Daniel Levy, Jiantao Ma   +10 more
doaj   +1 more source

The Formative Spirituality of John Punshon (1935-2017)

, 2017
John Punshon has been one of the premier Quaker historians and spokespersons over the last four decades. Serving as Quaker Tutor at Woodbrooke, Visiting Professor of Quaker Studies at George Fox University, and the first Geraldine Leatherock Chair of ...
Anderson, Paul N.
core