Results 151 to 160 of about 4,058,838 (360)

Resistance to bleomycin increases the chronological life of cells [PDF]

, 2019
The identification of genes involved in chronological aging could have a potential utility as molecular markers in the chemotherapy treatment of cancer.
Burgos-Molina, Antonio Manuel, Gil-Carmona, Luisa, Mercado-Sáenz, Silvia, Ruiz-Gomez, Miguel Jose   +3 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The impact of life events on health-related quality of life in rural older adults: the moderating role of social support

Frontiers in Public Health
BackgroundGlobal aging is one of the most significant social trends of the 21st century. Health-Related Quality of Life (HRQoL) is an important indicator not only for evaluating the effectiveness of medical interventions, public health policies, and ...
Lijun Liu, Jiaman Li, Yiwen Tang, Cheng Chen, Chan Yu, Xiaofeng Li, Li Peng, Daikun Zheng   +7 more
doaj   +1 more source

Characterization of the Evolution of IC Emissions after Accelerated Aging [PDF]

, 2009
9 pagesInternational audienceWith the evolving technological development of integrated circuits (ICs), ensuring electromagnetic compatibility (EMC) is becoming a serious challenge for electronic circuit and system manufacturers.
Ben Dhia, Sonia, Boyer, Alexandre, Guillot, Laurent, Ndoye Cisse, Amadou, Vrignon, Bertrand   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Dynamic accelerated stress test and coupled on-line analysis program to elucidate aging processes in proton exchange membrane fuel cells

Scientific Reports
The application of hydrogen proton exchange membrane fuel cells (PEMFC) in greenhouse gas emission free heavy-duty vehicles requires extremely durable PEMFC components with service lives in the range of 30,000 h.
Lena Birkner, Michael Foreta, Ali Rinaldi, Anton Orekhov, Marc-Georg Willinger, Maik Eichelbaum   +5 more
doaj   +1 more source

Accelerated Aging Experiments for Capacitor Health Monitoring and Prognostics [PDF]

This paper discusses experimental setups for health monitoring and prognostics of electrolytic capacitors under nominal operation and accelerated aging conditions.
Biswas, Gautam, Celaya, Jose Ramon, Goebel, Kai, Kulkarni, Chetan S.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source