Results 111 to 120 of about 5,863,535 (304)

Evidence for spinal disinhibition as a pain-generating mechanism in fibromyalgia syndrome

PAIN Reports
. Introduction:. Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the spinal cord, and 1 ...
Anne Marshall, Jamie Burgess, Andreas Goebel, Bernhard Frank, Uazman Alam, Andrew Marshall   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Health workforce strategies during COVID-19 response: insights from 15 countries in the WHO Africa Region

BMC Health Services Research
Introduction The COVID-19 pandemic unveiled huge challenges in health workforce governance in the context of public health emergencies in Africa. Several countries applied several measures to ensure access to qualified and skilled health workers to ...
Adam Ahmat, Sunny C Okoroafor, James Avoka Asamani, Millogo Jean, Abdou Illou Mourtala, Jennifer Nyoni, Kasonde Mwinga   +6 more
doaj   +1 more source

Women’s family histories and incomes in later life in the UK, US and West Germany [PDF]

Using data from several large scale longitudinal surveys, this paper investigates the relationship between older women's families histories and their personal incomes in later life in the UK, US and West Germany, By comparing three countries with very ...
Jane Falkingham, Maria Evandrou, Tom Sefton   +2 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome

Scientific Reports
A proportion of people with fibromyalgia demonstrate small fibre pathology (SFP). However, it is unclear how SFP directly relates to pain phenomenology. Thirty-three individuals with FMS and ten healthy volunteers underwent assessment of SFP and sensory ...
Anne Marshall, Leandros Rapteas, Jamie Burgess, David Riley, Matthew Anson, Kohei Matsumoto, Amanda Bennett, Stephen Kaye, Andrew Marshall, James Dunham, Nicholas Fallon, Sizheng S. Zhao, Anne Pritchard, Nicola Goodson, Rayaz A. Malik, Andreas Goebel, Bernhard Frank, Uazman Alam   +17 more
doaj   +1 more source

Sex Differences in Stroke Care and Outcomes: A National Stroke Registry Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous evidence on sex differences in stroke care and outcomes was limited in sample representativeness and coverage of care indicators. We aim to investigate various indicators of stroke care quality, survival, and functional outcome at ...
Min Xu, Youssef Hbid, Kaili Stanley, Charles Wolfe, Matthew D. L. O'Connell, Abdel Douiri   +5 more
doaj   +1 more source

A Life-Course Perspective Analysis on the Factors Affecting Neonatal Death in Bantul District, Yogyakarta [PDF]

, 2018
Background: Neonatal death is an important health outcome during the first year of life. According to WHO, 46% of deaths among children under five were newborns in 2016.
Listiani, F. R. (Funik), Murti, B. (Bhisma), Salimo, H. (Harsono)   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source