Results 131 to 140 of about 14,412,106 (353)

Sustainable Work Over the Life Course: Concept Paper [PDF]

, 2015
Ageing of the population is likely to threaten the ability of states to finance welfare states and social protection systems in the future. A viable solution is to increase employment rates and to lengthen working life. To achieve this dual goal requires
Eurofound
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PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Small fibre pathology, small fibre symptoms and pain in fibromyalgia syndrome

Scientific Reports
A proportion of people with fibromyalgia demonstrate small fibre pathology (SFP). However, it is unclear how SFP directly relates to pain phenomenology. Thirty-three individuals with FMS and ten healthy volunteers underwent assessment of SFP and sensory ...
Anne Marshall, Leandros Rapteas, Jamie Burgess, David Riley, Matthew Anson, Kohei Matsumoto, Amanda Bennett, Stephen Kaye, Andrew Marshall, James Dunham, Nicholas Fallon, Sizheng S. Zhao, Anne Pritchard, Nicola Goodson, Rayaz A. Malik, Andreas Goebel, Bernhard Frank, Uazman Alam   +17 more
doaj   +1 more source

Sex Differences in Stroke Care and Outcomes: A National Stroke Registry Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous evidence on sex differences in stroke care and outcomes was limited in sample representativeness and coverage of care indicators. We aim to investigate various indicators of stroke care quality, survival, and functional outcome at ...
Min Xu, Youssef Hbid, Kaili Stanley, Charles Wolfe, Matthew D. L. O'Connell, Abdel Douiri   +5 more
doaj   +1 more source

Women’s family histories and incomes in later life in the UK, US and West Germany [PDF]

Using data from several large scale longitudinal surveys, this paper investigates the relationship between older women's families histories and their personal incomes in later life in the UK, US and West Germany, By comparing three countries with very ...
Jane Falkingham, Maria Evandrou, Tom Sefton   +2 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Dandelion Program: 2016 in Review [PDF]

, 2017
[Excerpt] The Dandelion Program is an initiative to build valuable Information Technology, life, and executive functional skills to help establish careers for people on the autism spectrum. The implementation and assessment of Dandelion pods concentrates
DXC Technology
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Anticipatory analysis and its alternatives in life-course research [PDF]

In the second part of these reflections, we use the connection between marriage and first childbearing to demonstrate further issues involved in anticipatory analysis.
Jan M. Hoem, Michaela Kreyenfeld
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