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BNIP3-Dependent Mitophagy Non-Autonomously Regulates Systemic Aging via NF-κB Suppression in Drosophila. [PDF]

open access: yesAging Cell
Deng Z   +11 more
europepmc   +1 more source
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Bisphosphonates and lifespan

Bone, 2020
Bisphosphonates are first line agents used to treat osteoporosis and reduce fracture rate. They bind to areas of exposed calcium in the skeleton and cause osteoclast apoptosis, thereby leading to a reduction in remodelling rates. They are also used to decrease skeletal complications of some cancers including a reduction in bone metastases.
Jacqueline R, Center   +2 more
openaire   +2 more sources

Lifespan of lymphocytes

Immunologic Research, 1995
T and B lymphocytes comprise heterogeneous populations of cells at various stages of differentiation and activation. T- and B-cell subsets have different roles in the maintenance of immune homeostasis, and their functional differences are reflected by their respective lifespans.
D F, Tough, J, Sprent
openaire   +2 more sources

Limits to lifespan

Nature Cell Biology, 2002
It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential.
openaire   +2 more sources

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