Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs [PDF]
, 2008 The insulin/IGF-like signalling (IIS) pathway has diverse functions in all multicellular organisms, including determination of lifespan. The seven insulin-like peptides (DILPs) in Drosophila are expressed in a stage- and tissue-specific manner.
Vinti, Giovanna +9 more
core +6 more sources
Identification of sur2 mutation affecting the lifespan of fission yeast [PDF]
, 2021 Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2^+ gene ...
Ihara, Kunio +7 more
core +1 more source
The gustatory system influences "Drosophila" lifespan [PDF]
, 2011 The lifespan of an organism is affected by the complex interplay between genetic and environmental factors. In C. elegans, this interaction between genes and environment is mediated by the sensory system.
Ostojić, Ivan
core +1 more source
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan [PDF]
, 2015 Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear.
Wilson, Iain B H +31 more
core +2 more sources
Extension of Yeast Chronological Lifespan by Methylamine [PDF]
, 2012 Background: Chronological aging of yeast cells is commonly used as a model for aging of human post-mitotic cells. The yeast Saccharomyces cerevisiae grown on glucose in the presence of ammonium sulphate is mainly used in yeast aging research.
Lefevre Sophie D. +16 more
core +3 more sources
“Whey Aye My Good Sir”: Has Cheryl Fernandez-Versini’s Accent Moved from Tyneside English to RP?
Lifespans and Styles, 2016 This article analyses the speech of Cheryl Fernandez-Versini (nee Tweedy, formerly Cole), henceforth “Cheryl” , who experienced rapid geographical and socioeconomic mobility between 2002 and 2014.
Victoria Wallace
doaj +1 more source
Identification of a novel protein kinase that affects the chronological lifespan in fission yeast [PDF]
, 2017 Chronological lifespan is defined by how long a cell can survive in a non-dividing state. In yeast, it is measured by viability after entry into the stationary phase.
Ihara, Kunio +7 more
core +1 more source
Sixty Years of Speech: A Study of Language Change in Adulthood
Lifespans and Styles, 2016 Research on language change has been complicated and hindered by the problem of obtaining quality data. In many cases, the large volume of time required to collect recorded speech at different intervals, as necessary in lifespan studies, is prohibitive ...
Bei Qing Cham
doaj +1 more source
Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster. [PDF]
PLoS ONE, 2018 Autophagy is a highly conserved mechanism for cellular repair that becomes progressively down-regulated during normal ageing. Hence, manipulations that activate autophagy could increase lifespan.
Janet S Mason +2 more
doaj +1 more source
‘Ow Cockney is Beckham Twenty Years On? An Investigation into H-dropping and T-glottaling
Lifespans and Styles, 2016 This research paper examines how language change can occur across the lifespan through the linguistic analysis of East Londoner, and world renowned football player, David Beckham.
Sofia Dahou, Jasmine Hamlin
doaj +1 more source