Results 41 to 50 of about 467,497 (301)
Lifespan Changes of the Human Brain In Alzheimer’s Disease [PDF]
Scientific Reports, 2019 AbstractBrain imaging studies have shown that slow and progressive cerebral atrophy characterized the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated to AD, key questions about the lifespan evolution of AD biomarkers remain open. When does the AD model diverge from the normal aging model?
Pierrick Coupé +3 more
openaire +5 more sources
A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia
eLife, 2017 The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice.
Nathan G Skene +2 more
doaj +1 more source
Individual and group level personality change across the lifespan in dogs
Scientific Reports, 2020 In humans, age-related changes in personality occur in a non-random fashion with respect to their direction, timing, and magnitude. In dogs, there are still gaps in our knowledge about the detailed dynamics of age-related personality changes. We analysed
Borbála Turcsán +5 more
doaj +1 more source
PURR - The Persistent URL Resource Resolver [PDF]
, 2001 URLs have a precarious functional lifespan. They resolve the intended target (web page, PDF, audio stream, and so on) only so long as the target is available, otherwise they'll point to a dead end.
Sponsler, Ed
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash +4 more
wiley +1 more source
Time indeterminacy and spatio-temporal building transformations: an approach for architectural heritage understanding [PDF]
, 2009 Nowadays most digital reconstructions in architecture and archeology describe buildings heritage as awhole of static and unchangeable entities. However, historical sites can have a rich and complex history, sometimes full of evolutions, sometimes only ...
DE LUCA, Livio +2 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila [PDF]
, 2018 Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure.
Hartley, Paul S. +3 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Primary headaches during lifespan
The Journal of Headache and Pain, 2019 Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of symptoms within every headache attack.
Andreas Straube, Anna Andreou
doaj +1 more source