Results 61 to 70 of about 467,497 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A link between phenotypic robustness and life expectancy in Drosophila melanogaster

Вавиловский журнал генетики и селекции, 2017
Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of ...
L. P. Zakharenko, D. V. Petrovskii, I. G. Dranov, S. A. Fedorova, N. S. Yudin, A. V. Pindyurin, Y. M.  Moshkin   +6 more
doaj   +1 more source

Use of Carboxyhemoglobin as an Early Sign of Oxygenator Dysfunction in Patients Supported by Extracorporeal Membrane Oxygenation

Frontiers in Medicine, 2022
IntroductionPlasma free hemoglobin is the gold standard for monitoring hemolysis in extracorporeal membrane oxygenation (ECMO) but its routine use has some limitations. Carboxyhemoglobin (HbCO) is also a marker of intravascular hemolysis.
Vladimir L. Cousin, Vladimir L. Cousin, Raphaël Giraud, Raphaël Giraud, Benjamin Assouline, Benjamin Assouline, Ivo Neto Silva, Ivo Neto Silva, Karim Bendjelid, Karim Bendjelid   +9 more
doaj   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Research on Life Extension of Primary Rubber Springs for Railway Vehicles

机车电传动, 2021
In order to understand and master the real change after the operation of a lifespan (5 years or 600,000 km) of the primary conical rubber spring, which is a critical part for railway vehicles, and to provide data support for life extension research and ...
Yunjie FAN, Yuxiang ZHANG, Haiming TAN, Zhiguo LI, Jun LUO, Zhongsan JIANG   +5 more
doaj  

Interleaved Pro/Anti-saccade Behavior Across the Lifespan

Frontiers in Aging Neuroscience, 2022
The capacity for inhibitory control is an important cognitive process that undergoes dynamic changes over the course of the lifespan. Robust characterization of this trajectory, considering age continuously and using flexible modeling techniques, is ...
Rachel Yep, Matthew L. Smorenburg, Heidi C. Riek, Olivia G. Calancie, Ryan H. Kirkpatrick, Ryan H. Kirkpatrick, Julia E. Perkins, Jeff Huang, Brian C. Coe, Donald C. Brien, Douglas P. Munoz, Douglas P. Munoz, Douglas P. Munoz   +12 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fundamental equations linking methylation dynamics to maximum lifespan in mammals

Nature Communications
We describe a framework that addresses concern that the rate of change in any aging biomarker displays a trivial inverse relation with maximum lifespan. We apply this framework to methylation data from the Mammalian Methylation Consortium.
Steve Horvath, Joshua Zhang, Amin Haghani, Ake T. Lu, Zhe Fei   +4 more
doaj   +1 more source

Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan in Drosophila melanogaster

Frontiers in Genetics, 2020
Most eukaryotic genes express multiple transcripts and proteins, and a sophisticated gene expression strategy plays a crucial role in ensuring the cell-specificity of genetic information and the correctness of phenotypes. The Drosophila melanogaster gene
Mikhail V. Trostnikov, Ekaterina R. Veselkina, Anna V. Krementsova, Anna V. Krementsova, Stepan V. Boldyrev, Stepan V. Boldyrev, Natalia V. Roshina, Natalia V. Roshina, Elena G. Pasyukova   +8 more
doaj   +1 more source