Results 71 to 80 of about 5,941,001 (258)

Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation. [PDF]

The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to date.
Boomsma, Dorret I, Boomsma, D., Buckner, R., Walter, H., Glahn, David C, Schumann, G., Frangou, Sophia, Boomsma, Dorret, Tamnes, Christian, Yu, Yuetong, Gruber, O., Crone, Eveline, Brodaty, H., Thompson, Paul, Brouwer, R., Glahn, David, Caseras, X., Thompson, Paul M, Wierenga, L., Crone, E., Glahn, D., Crivello, Fabrice, Walter, Henrik, Brouwer, Rachel M, New, Faye, Jahanshad, N., Qi, Y., Haas, S., Crone, Eveline A, New, F., Ge, Ruiyang, Fan, Y., Erk, Susanne, Tamnes, Christian K, Yu, Y., Ge, R., Qi, Yi Xuan, Qi, Yi, Buckner, Randy, Grotegerd, D., Tamnes, C., Thompson, P., Jahanshad, Neda, Haas, Shalaila, Haas, Shalaila S, Franke, Barbara, Grotegerd, Dominik, Brodaty, Henry, Brouwer, Rachel, Fisher, Simon E, Franke, B., Dannlowski, U., Fisher, S., Erk, S., Gao, Chuntong, Wierenga, Lara, Fisher, Simon, Gao, C., Gruber, Oliver, Schumann, Gunter, Chen, Shiyu, Chen, S., Wierenga, Lara M, Hulshoff Pol, Hilleke E, Dannlowski, Udo, Fan, Yu-Nan, Caseras, Xavier, Hulshoff Pol, Hilleke, Crivello, F., Hulshoff Pol, H., ENIGMA Lifespan Working Group, Frangou, S.   +71 more
core   +3 more sources

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

Genome Biology, 2017
Background Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by ...
Tina Wang, Brian Tsui, Jason F. Kreisberg, Neil A. Robertson, Andrew M. Gross, Michael Ku Yu, Hannah Carter, Holly M. Brown-Borg, Peter D. Adams, Trey Ideker   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Handedness throughout the lifespan: Cross-sectional view on sex differences as asymmetries change

Frontiers in Psychology, 2015
Manual asymmetries has been studied by many researchers, however contradictory findings still exist as to whether preferred manual asymmetries increases with age or do we become more ambidextrous.
Mukundhan eSivagnanasunderam, David A Gonzalez, Pamela J Bryden, Gordon eYoung, Amanda eForsyth, Eric A Roy   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Developmental cognitive neuroscience using latent change score models: A tutorial and applications

Developmental Cognitive Neuroscience, 2018
Assessing and analysing individual differences in change over time is of central scientific importance to developmental neuroscience. However, the literature is based largely on cross-sectional comparisons, which reflect a variety of influences and ...
Rogier A. Kievit, Andreas M. Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M.M. de Mooij, Michael Moutoussis, Ian M. Goodyer, Ed Bullmore, Peter B. Jones, Peter Fonagy, Ulman Lindenberger, Raymond J. Dolan   +11 more
doaj   +1 more source

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex. [PDF]

Elife, 2023
Roe JM, Vidal-Pineiro D, Amlien IK, Pan M, Sneve MH, Thiebaut de Schotten M, Friedrich P, Sha Z, Francks C, Eilertsen EM, Wang Y, Walhovd KB, Fjell AM, Westerhausen R.   +13 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source