Results 71 to 80 of about 162,248 (302)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Research on Life Extension of Primary Rubber Springs for Railway Vehicles
机车电传动, 2021 In order to understand and master the real change after the operation of a lifespan (5 years or 600,000 km) of the primary conical rubber spring, which is a critical part for railway vehicles, and to provide data support for life extension research and ...
Yunjie FAN +5 more
doaj
Interleaved Pro/Anti-saccade Behavior Across the Lifespan
Frontiers in Aging Neuroscience, 2022 The capacity for inhibitory control is an important cognitive process that undergoes dynamic changes over the course of the lifespan. Robust characterization of this trajectory, considering age continuously and using flexible modeling techniques, is ...
Rachel Yep +12 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
The increasing lifespan variation gradient by area-level deprivation: a decomposition analysis of Scotland 1981-2011 [PDF]
, 2019 Life expectancy inequalities are an established indicator of health inequalities. More recent attention has been given to lifespan variation, which measures the amount of heterogeneity in age at death across all individuals in a population. International
van Raalte, A. +10 more
core +1 more source
Frontiers in Genetics, 2020 Most eukaryotic genes express multiple transcripts and proteins, and a sophisticated gene expression strategy plays a crucial role in ensuring the cell-specificity of genetic information and the correctness of phenotypes. The Drosophila melanogaster gene
Mikhail V. Trostnikov +8 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2019 The effects of climate change on solitary bee species, the most diverse and abundant group of wild pollinators, remain poorly understood, limiting our ability to forecast consequences for bee-plant interactions and pollination services.
Anthony H. Slominski, Laura A. Burkle
doaj +1 more source