Results 71 to 80 of about 467,497 (301)
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Lifespan Trajectories of White Matter Changes in Rhesus Monkeys [PDF]
Cerebral Cortex, 2018 Progress in neurodevelopmental brain research has been achieved through the use of animal models. Such models not only help understanding biological changes that govern brain development, maturation and aging, but are also essential for identifying possible mechanisms of neurodevelopmental and age-related chronic disorders, and to evaluate possible ...
M, Kubicki +16 more
openaire +2 more sources
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2019 The effects of climate change on solitary bee species, the most diverse and abundant group of wild pollinators, remain poorly understood, limiting our ability to forecast consequences for bee-plant interactions and pollination services.
Anthony H. Slominski, Laura A. Burkle
doaj +1 more source
Review of the school workload advisory panel: final report [PDF]
, 2009 The School Workload Advisory Panel (SWAP) was established as an independent body in 2004 by the Welsh Assembly Government with a remit that was aimed at reducing bureaucratic burdens on schools.
core
Skeletal changes through the lifespan—from growth to senescence [PDF]
Nature Reviews Endocrinology, 2015 Age-related fragility fractures are an enormous public health problem. Both acquisition of bone mass during growth and bone loss associated with ageing affect fracture risk late in life. The development of high-resolution peripheral quantitative CT (HRpQCT) has enabled in vivo assessment of changes in the microarchitecture of trabecular and cortical ...
Joshua N, Farr, Sundeep, Khosla
openaire +2 more sources
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]
, 2015 Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming +16 more
core +1 more source
Changes in REM-Sleep Percentage Over the Adult Lifespan [PDF]
Sleep, 2007 To resolve inconsistencies in previously reported changes in percentage of rapid eye movement sleep (REM%) over the adult lifespan and to identify gaps in available information about adults' REM sleep.A research synthesis approach specifically designed to detect nonlinear change.
Judith A, Floyd +3 more
openaire +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source