Results 91 to 100 of about 162,248 (302)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast [PDF]

, 2020
Amino acid deprivation or supplementation can affect cellular and organismal lifespan, but we know little about the role of concentration changes in free, intracellular amino acids during aging.
Au, Yan Zi, Yan Zi Au, Bähler, J, Bähler, Jürg, Rallis, Charalampos, Smith, Graeme, Ralser, M, Mülleder, M, Charalampos Rallis, Michael Mülleder, Graeme Smith, Rallis, C, Jürg Bähler, Mülleder, Michael, Markus Ralser, Smith, G, Au, YZ, Ralser, Markus   +17 more
core   +1 more source

Developmental cognitive neuroscience using latent change score models: A tutorial and applications

Developmental Cognitive Neuroscience, 2018
Assessing and analysing individual differences in change over time is of central scientific importance to developmental neuroscience. However, the literature is based largely on cross-sectional comparisons, which reflect a variety of influences and ...
Rogier A. Kievit, Andreas M. Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M.M. de Mooij, Michael Moutoussis, Ian M. Goodyer, Ed Bullmore, Peter B. Jones, Peter Fonagy, Ulman Lindenberger, Raymond J. Dolan   +11 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Psychologie développementale du lifespan [PDF]

, 2007
Depuis ses origines jusque vers la fin des années 1960, la psychologie du développement s'est centrée sur l'étude des changements dans le fonctionnement psychologique de l'enfant, et en partie de l'adolescent.
Delphine Fagot, Fagot, Delphine, Lecerf, Thierry, De Ribaupierre, Anik, Judith Dirk, Dirk, Judith, Anik De Ribaupierre, Thierry Lecerf   +7 more
core   +1 more source

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex. [PDF]

Elife, 2023
Roe JM, Vidal-Pineiro D, Amlien IK, Pan M, Sneve MH, Thiebaut de Schotten M, Friedrich P, Sha Z, Francks C, Eilertsen EM, Wang Y, Walhovd KB, Fjell AM, Westerhausen R.   +13 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mouse Lifespan Synaptome Atlas dataset [PDF]

, 2019
How synapses change molecularly during the lifespan and across all brain circuits is unknown. We analyzed the protein composition of billions of individual synapses from birth to old age on a brain-wide scale in the mouse, revealing a program of changes ...
Qiu, Ricky, Koniaris, Babis, School of Regeneration and Repair, Edinburgh Neuroscience, Grant, Seth, Fransen, Erik, Centre for Clinical Brain Sciences, Cizeron, Mélissa, Komiyama, Noboru, Gokhale, R   +9 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source