Results 81 to 90 of about 467,497 (301)
Genome Biology, 2018 Background Mammalian species exhibit a wide range of lifespans. To date, a robust and dynamic molecular readout of these lifespan differences has not yet been identified.
Robert Lowe +13 more
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Coupling metabolic footprinting and flux balance analysis to predict how single gene knockouts perturb microbial metabolism [PDF]
, 2012 Tese de mestrado. Biologia (Bioinformática e Biologia Computacional). Universidade de Lisboa, Faculdade de Ciências, 2012The model organisms Caenorhabditis elegans and E. coli form one of the simplest gut microbe host interaction models. Interventions in
Correia, Gonçalo dos Santos, 1989-
core
Adaptation, stress, and coping in sport [PDF]
Adaptation, which was mentioned within the domain of stress and coping research by Lazarus (1991), refers to the way in which people change according to the world that they live in.
Nicholls, Adam
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It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Genome Biology, 2017 Background Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by ...
Tina Wang +9 more
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On the relationship between period and cohort mortality [PDF]
In this paper I explore the formal relationship between period and cohort mortality, focusing on a comparison of measures of mean lifespan. I consider not only the usual measures (life expectancy at birth for time periods and birth cohorts) but also some
John R. Wilmoth
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Decadal-centennial scale monsoon variations in the Arabian Sea during the Early Holocene [PDF]
, 2002 An essential prerequisite for the prediction of future climate change due to anthropogenic input is an understanding of the natural processes that control Earth's climate on timescales comparable to human-lifespan. The Early Holocene period was chosen to
Anderson +26 more
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Handedness throughout the lifespan: Cross-sectional view on sex differences as asymmetries change
Frontiers in Psychology, 2015 Manual asymmetries has been studied by many researchers, however contradictory findings still exist as to whether preferred manual asymmetries increases with age or do we become more ambidextrous.
Mukundhan eSivagnanasunderam +5 more
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