Results 31 to 40 of about 5,941,001 (258)
A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia
eLife, 2017 The genetic mechanisms regulating the brain and behaviour across the lifespan are poorly understood. We found that lifespan transcriptome trajectories describe a calendar of gene regulatory events in the brain of humans and mice.
Nathan G Skene +2 more
doaj +1 more source
50 years of British accent bias: Stability and lifespan change in attitudes to accents [PDF]
, 2021 Do accent biases observed half a century ago (Giles 1970) and 15 years ago (Coupland & Bishop 2007) still hold today in Britain? We provide an updated picture of national attitudes to accent labels by replicating and extending previous studies.
Levon, Erez +6 more
core +2 more sources
Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae
Microbial Cell, 2019 In many plants and microorganisms, intracellular proline has a protective role against various stresses, including heat-shock, oxidation and osmolarity. Environmental stresses induce cellular senescence in a variety of eukaryotes.
Yukio Mukai +7 more
doaj +1 more source
Individual and group level personality change across the lifespan in dogs
Scientific Reports, 2020 In humans, age-related changes in personality occur in a non-random fashion with respect to their direction, timing, and magnitude. In dogs, there are still gaps in our knowledge about the detailed dynamics of age-related personality changes. We analysed
Borbála Turcsán +5 more
doaj +1 more source
Effects of Increased Flight on the Energetics and Life History of the Butterfly Speyeria mormonia. [PDF]
PLoS ONE, 2015 Movement uses resources that may otherwise be allocated to somatic maintenance or reproduction. How does increased energy expenditure affect resource allocation?
Kristjan Niitepõld, Carol L Boggs
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Lifespan perceptions of event-related personality change
, 2022 In this pre-registration, we outline how we will describe perceptions of event-related personality change across the ...
Chris Hopwood +4 more
core +1 more source
Primary headaches during lifespan
The Journal of Headache and Pain, 2019 Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of symptoms within every headache attack.
Andreas Straube, Anna Andreou
doaj +1 more source