Results 61 to 70 of about 2,003,877 (281)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Adiposity and changes in movement-related behaviors in older adult women in the context of the built environment: a protocol for a prospective cohort study

open access: yesBMC Public Health, 2019
Background In older adults, sedentary behaviors increase while physical activity decreases over time following the compositional nature of 24-h behaviors.
Roman Cuberek   +7 more
doaj   +1 more source

A qualitative study evaluating experiences of a lifestyle intervention in men with prostate cancer undergoing androgen suppression therapy [PDF]

open access: yes, 2012
BACKGROUND The severe iatrogenic hypogonadal state induced by medical castration used for treatment of prostate cancer is associated with adverse effects including fatigue, increased fracture risk, and a decrease in skeletal muscle function, which ...
Bourke, Liam   +5 more
core   +2 more sources

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

'tits and ass and porn and fighting': male heterosexuality in magazines for men [PDF]

open access: yes, 2005
This paper examines the presentation of male heterosexuality in British soft core pornographic and men’s lifestyle magazines, looking across these formats at the range of conventions and discourses they share.
Attwood, F.
core   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu   +16 more
wiley   +1 more source

Prevalence of malnutrition among Samoan children aged 5 to 11 years in 2019–2020

open access: yesAnnals of Human Biology, 2023
Background Globally, rapid economic development, urbanisation, and nutrition transitions have led to rising levels of malnutrition in all forms. Aim The study objective was to document the prevalence of overweight/obesity, underweight, stunting, and ...
Courtney C. Choy   +10 more
doaj   +1 more source

'Working our way to health': Final Evaluation Report [PDF]

open access: yes, 2009
This summary presents the findings of an independent evaluation of the ‘Working our Way to Health’ programme. This programme was delivered by Sefton PCT, funded through the Neighbourhood Renewal Fund, and was aimed at improving the health of men in three
Hacking, S, Robertson, S, Robinson, M
core  

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

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