Results 51 to 60 of about 73,179 (247)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Application of Hardware-in-the-Loop Simulation Technology in Life Prediction of IGBT Module for Rail Transit

机车电传动, 2019
IGBT module is the core component of the train traction converter, its life prediction technology is an important basis for the prognostic and health management of the whole train.
Lin CAO, Na YE, Ping LI, Bishan LI, Hong CHEN, Cailin WANG   +5 more
doaj  

Substantiation of FAC rate and service life estimation under operation control data

Nuclear Energy and Technology, 2016
Flow-accelerated corrosion (FAC) wear is the complex mechanism of damage of elements of NPP equipment and pipelines. FAC rate is determined by such factors as corrosion of metal, flow hydrodynamics, geometry of equipment elements and pipelines, applied ...
V.I. Baranenko, O.M. Gulina, N.L. Salnikov, O.E. Murzina   +3 more
doaj   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Beam-beam effects investigation and parameters optimization for a circular e^{+}e^{-} collider at very high energies

Physical Review Special Topics. Accelerators and Beams, 2014
Several proposals exist for future circular electron-positron colliders designed for precise measurements of the Higgs boson characteristics and electroweak processes.
A. Bogomyagkov, E. Levichev, D. Shatilov
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Soil Load on Plastic Pipe and its Influence on Lifetime

Journal of Mechanical Engineering, 2019
Lifetime of plastic pipes can be estimated by integration of a power law describing the crack kinetics. However, this procedure requires an FEM (finite element method) calculation of the possible crack propagation in the pipe to obtain stress intensity ...
Poduška Jan, Hutař Pavel, Frank Andreas, Kučera Jaroslav, Sadílek Jiří, Pinter Gerald, Náhlík Luboš   +6 more
doaj   +1 more source

Lifetime Analysis of IGBT Power Modules in Passively Cooled Tidal Turbine Converters

Energies, 2020
Thermal cycling is one of the major reasons for failure in power electronic converters. For submerged tidal turbine converters investigating this failure mode is critical in improving the reliability, and minimizing the cost of energy from tidal turbines.
Faisal Wani, Udai Shipurkar, Jianning Dong, Henk Polinder, Antonio Jarquin-Laguna, Kaswar Mostafa, George Lavidas   +6 more
doaj   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source