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Interaction of Calreticulin with CD40 Ligand, TRAIL and Fas Ligand
Scandinavian Journal of Immunology, 2007AbstractThe molecular chaperone calreticulin has been shown to bind C1q and mannan‐binding lectin (MBL), which are constituents of the innate immune defence system. C1q and MBL do not share a large sequence identity but have a similar overall molecular architecture: an N‐terminal triple‐helical collagen‐like domain and a C‐terminal globular domain with
Duus, K. +5 more
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Journal of Chemical Information and Modeling, 2005
From the historically grown archive of protein-ligand complexes in the Protein Data Bank small organic ligands are extracted and interpreted in terms of their chemical characteristics and features.
Gerhard Wolber, T. Langer
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From the historically grown archive of protein-ligand complexes in the Protein Data Bank small organic ligands are extracted and interpreted in terms of their chemical characteristics and features.
Gerhard Wolber, T. Langer
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Journal of Chemical Theory and Computation, 2011
The new empirical rules for protein pKa predictions implemented in the PROPKA3.0 software package (Olsson et al. J. Chem. Theory Comput.2010, 7, 525-537) have been extended to the prediction of pKa shifts of active site residues and ionizable ligand ...
Chresten R. Søndergaard +3 more
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The new empirical rules for protein pKa predictions implemented in the PROPKA3.0 software package (Olsson et al. J. Chem. Theory Comput.2010, 7, 525-537) have been extended to the prediction of pKa shifts of active site residues and ionizable ligand ...
Chresten R. Søndergaard +3 more
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Cannabinoid Receptors and Their Ligands: Ligand—Ligand and Ligand—Receptor Modeling Approaches
2005The cannabinoid CB1 and CB2 receptors belong to the class A, rhodopsin-like family of GPCRs. Antagonists for each receptor sub-type, as well as four structural classes of agonists that bind to both receptors, have been identified. An extensive amount of structure-activity relationship information (SAR) has been developed for agonists and antagonists ...
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The International Journal of Biochemistry & Cell Biology, 2007
RANK ligand (RANKL), a key mediator of bone resorption in normal and pathological states, is expressed as membrane-bound or soluble forms by tissues as diverse as lymph nodes, spleen, thymus and bone-forming cells. In normal bone turnover and in bone metastasis, RANKL stimulates the formation and activity of bone-removing cells, osteoclasts, by binding
J M, Blair, Y, Zheng, C R, Dunstan
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RANK ligand (RANKL), a key mediator of bone resorption in normal and pathological states, is expressed as membrane-bound or soluble forms by tissues as diverse as lymph nodes, spleen, thymus and bone-forming cells. In normal bone turnover and in bone metastasis, RANKL stimulates the formation and activity of bone-removing cells, osteoclasts, by binding
J M, Blair, Y, Zheng, C R, Dunstan
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2001
Sialic acids (Sia) are derivatives of the nine-carbon neuraminic acid monosaccharide (Fig. 1). To date, about 40 of these neuraminic acid modifications have been found to occur in nature (Table 1). Their structure, occurrence and metabolic pathways have been reviewed in detail (Rosenberg 1995; Kelm and Schauer 1997; Schauer and Kamerling 1997; Varki ...
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Sialic acids (Sia) are derivatives of the nine-carbon neuraminic acid monosaccharide (Fig. 1). To date, about 40 of these neuraminic acid modifications have been found to occur in nature (Table 1). Their structure, occurrence and metabolic pathways have been reviewed in detail (Rosenberg 1995; Kelm and Schauer 1997; Schauer and Kamerling 1997; Varki ...
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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.
Annual Review of Biochemistry, 1995Cytokines and growth factors regulate multiple aspects of cell growth through their interactions with specific receptors. These receptors initiate signals directed at both the cytoplasmic and the nuclear compartments.
C. Schindler, Jr Je Darnell
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The Selectins and Their Ligands
1993Among the four major groups of cell adhesion molecules (CAMs) the selectins represent the smallest and most recently identified gene family (Lasky 1992; Vestweber 1992). In contrast to the three large families of the integrins, the immunoglobulin super gene family and the cadherins, the selectins consist of only three members: L-, E-, and P-selectin ...
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Searching for peptide ligands with an epitope library.
Science, 1990Tens of millions of short peptides can be easily surveyed for tight binding to an antibody, receptor or other binding protein using an "epitope library." The library is a vast mixture of filamentous phage clones, each displaying one peptide sequence on ...
J. Scott, George P Smith
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New chiral phosphorus ligands for enantioselective hydrogenation.
Chemical Reviews, 2003The increasing demand to produce enantiomerically pure pharmaceuticals, agrochemicals, flavors, and other fine chemicals has advanced the field of asymmetric catalytic technologies.1,2 Among all asymmetric catalytic methods, asymmetric hydrogenation ...
Wenjun Tang, Xumu Zhang
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