Results 51 to 60 of about 8,570,567 (357)

Collective Light Emission of a Finite Size Atomic Chain

open access: yes, 2012
Radiative properties of collective electronic states in a one dimensional atomic chain are investigated. Radiative corrections are included with emphasize put on the effect of the chain size through the dependence on both the number of atoms and the ...
Agranovich V. M.   +12 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The role of notch signaling pathway and non-coding RNAs in cancer and inflammation: progress, therapeutic insights, and future directions

open access: yesFrontiers in Immunology
The Notch signaling pathway and non-coding RNAs (ncRNAs) play significant roles in regulating key cellular processes such as cancer progression, metastasis, and drug resistance.
Rong-Zu Nie   +15 more
doaj   +1 more source

A Bayesian approach to the analysis of time symmetry in light curves: Reconsidering Scorpius X-1 occultations

open access: yes, 2009
We present a new approach to the analysis of time symmetry in light curves, such as those in the x-ray at the center of the Scorpius X-1 occultation debate.
Alexander W. Blocker   +14 more
core   +1 more source

Directional motion of forced polymer chains with hydrodynamic interaction [PDF]

open access: yes, 2012
We study the propulsion of a one-dimensional (1D) polymer chain under sinusoidal external forces in the overdamped (low Reynolds number) regime. We show that, when hydrodynamical interactions are included, the polymer presents directional motion which ...
A. Fiasconaro   +4 more
core   +3 more sources

Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2018

open access: yesBlood Cancer Journal, 2018
Immunoglobulin light chain amyloidosis (AL) should be considered in any patient that presents to a cancer care provider with nephrotic range proteinuria, heart failure with preserved ejection fraction, non-diabetic peripheral neuropathy, unexplained ...
M. Gertz
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Research on non-destructive detection of chilled meat quality based on hyperspectral technology combined with different data processing methods

open access: yesFrontiers in Nutrition
This study utilized hyperspectral technology in conjunction with chemometric methods for the non-destructive assessment of chilled meat quality. Average spectra were extracted from regions of interest within hyperspectral images and further optimized ...
Zeyu Xu   +25 more
doaj   +1 more source

Age- and activity-related differences in the abundance of Myosin essential and regulatory light chains in human muscle [PDF]

open access: yes, 2016
Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but
Burniston, Jatin G.   +5 more
core   +4 more sources

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

open access: yesNature Communications, 2019
Amyloid fibrils derived from antibody light chains are key pathogenic agents in systemic AL amyloidosis. They can be deposited in multiple organs but cardiac amyloid is the major risk factor of mortality.
L. Radamaker   +8 more
semanticscholar   +1 more source

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