Results 61 to 70 of about 2,711,435 (306)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration

Frontiers in Bioengineering and Biotechnology
This review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration.
Yaping Liu, Yaping Liu, Yaping Liu, Xiaoxiao Wang, Xiaoxiao Wang, Xiaoxiao Wang, Xingyue Tao, Xingyue Tao, Xingyue Tao, Hao-Kun Zhang, Hao-Kun Zhang, Hao-Kun Zhang, Bingyan Liu, Bingyan Liu, Bingyan Liu, Yilin Li, Yilin Li, Yilin Li, Hang Wang, Hang Wang, Hang Wang, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Peifeng Li, Peifeng Li, Peifeng Li   +29 more
doaj   +1 more source

Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. [PDF]

, 2019
Drosophila CRYPTOCHROME (dCRY) mediates electrophysiological depolarization and circadian clock resetting in response to blue or ultraviolet (UV) light.
Au, David D, Baik, Lisa S, Enrriquez-Villalva, Wendy K, Foden, Alexander J, Holmes, Todd C, Nave, Ceazar   +5 more
core   +1 more source

Collective shift in resonant light scattering by a one-dimensional atomic chain

, 2020
We experimentally study resonant light scattering by a one-dimensional randomly filled chain of cold two-level atoms. By a local measurement of the light scattered along the chain, we observe constructive interferences in light-induced dipole-dipole ...
Brossard, Ludovic, Browaeys, Antoine, Ferioli, Giovanni, Ferrier-Barbut, Igor, Glicenstein, Antoine, Sibalic, Nikola   +5 more
core   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Isolation and characterization of a light chain variable region gene for human rheumatoid factors. [PDF]

, 1987
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF ...
Carson, DA, Chen, PP, Jirik, FR, Kipps, TJ, Robbins, DL   +4 more
core  

Critical chain length and superconductivity emergence in oxygen-equalized pairs of YBa2Cu3O6.30

, 2000
The oxygen-order dependent emergence of superconductivity in YBa2Cu3O6+x is studied, for the first time in a comparative way, on pair samples having the same oxygen content and thermal history, but different Cu(1)Ox chain arrangements deriving from their
Allodi, G., Calestani, G., De Renzi, R., Manca, P., Migliori, A., Sanna, S.   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Flashing LEDs for microalgal production [PDF]

, 2017
Flashing lights are next-generation tools to mitigate light attenuation and increase the photosynthetic efficiency of microalgal cultivation systems illuminated by light-emitting diodes (LEDs).
Guerra, Rui Manuel Farinha das Neves, J. C. or Varela J. or Varela J.C.S., Varela, Lisa Schueler, Lisa M. Schueler, Pereira, Hugo, Schulze, Peter S.C.   +4 more
core   +1 more source