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Mediterranean Journal of Hematology and Infectious Diseases, 2018 Light chain (AL) amyloidosis is caused by a usually small plasma-cell clone that is able to produce the amyloidogenic lights chains. They are able to misfold and aggregate, deposit in tissues in the form of amyloid fibrils and lead to irreversible organ ...
Paolo Milani +2 more
doaj +4 more sources
Hereditary systemic immunoglobulin light-chain amyloidosis [PDF]
Blood, 2015 Key PointsProtein and DNA analyses reveal that mutation in the immunoglobulin κ light-chain constant region gene may cause hereditary amyloidosis. Sequencing of immunoglobulin light-chain constant region genes is indicated for patients with AL amyloidosis and no evidence of a plasma cell dyscrasia.
Benson, Merrill D. +2 more
openaire +5 more sources
Localized Lymph Node Light Chain Amyloidosis [PDF]
Case Reports in Hematology, 2015 Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and ...
Binod Dhakal +3 more
doaj +3 more sources
An atypical cause of amyloidosis: a case of combined heavy and light chain amyloidosis [PDF]
BMC NephrologyBackground The International Society of Amyloidosis recognizes 15 types of kidney-related amyloidosis, with most studies identifying immunoglobulin light chain (AL) amyloidosis as the leading cause in over half of these cases.
Dina R. Gonzalez-Hernandez +2 more
doaj +2 more sources
Emerging Therapeutics for the Treatment of Light Chain and Transthyretin Amyloidosis [PDF]
JACC: Basic to Translational Science, 2019 Summary: Cardiac amyloidosis is a restrictive cardiomyopathy that results from the deposition of misfolded light chain or transthyretin proteins, most commonly, in cardiac tissue.
Kathleen W. Zhang, MD +2 more
doaj +3 more sources
Light-chain amyloidosis with dysphagia as the main symptom: a case report [PDF]
Journal of Medical Case ReportsBackground Immunoglobulin light-chain amyloidosis is a relatively rare condition with a worldwide incidence of 5.1–12.8 cases per million person-years (Baker, 2022).
Maomao Ai +5 more
doaj +2 more sources
Novel Therapies in Light Chain Amyloidosis [PDF]
Kidney International Reports, 2018 Light chain (AL) amyloidosis is the most common form of amyloidosis involving the kidney. It is characterized by albuminuria, progressing to overt nephrotic syndrome and eventually end-stage renal failure if diagnosed late or ineffectively treated, and ...
Paolo Milani +2 more
doaj +4 more sources
Predicting survival in light chain amyloidosis
Haematologica, 2019 In this issue of the Journal, Dittrich and coworkers report their systematic analysis of the performance of the three currently used staging systems for AL amyloidosis in a large population of 1,224 patients.[1][1] Their aim was to establish whether one of the available models had ...
Giovanni Palladini +2 more
doaj +4 more sources
Light-Chain Cardiac Amyloidosis
JACC: Case Reports, 2019 Gonzalo Barge-Caballero, MD +2 more
doaj +3 more sources
Strong positive light chain immunostaining in a patient with transthyretin amyloidosis
Hematology, 2023 The two most common systemic amyloidosis types are immunoglobulin light chain (AL) and amyloid transthyretin (ATTR) amyloidosis, in which the precursor proteins responsible for amyloidosis are light chain and transthyretin, respectively.
Jiao Chen +5 more
doaj +1 more source