Results 71 to 80 of about 20,876 (147)

A murine model of amyloid‐enhanced tauopathy: Comparison of wild‐type and P301L‐tau

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION To optimize a model of amyloid‐enhanced tauopathy we compared wild‐type (WT) tau with P301L‐tau in a mouse with mature amyloid. METHODS Mice transgenic for amyloid precursor protein and presenilin‐1 (APP+PS1, A/P) were injected intravenously with adeno‐associated virus with capsid B10 (AAV.CAP‐B10) expressing either WT or P301L ...
Dylan J. Finneran, Taylor Desjarlais, Brianna M. Jackman, Marcia N. Gordon, David Morgan   +4 more
wiley   +1 more source

Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics

Haematologica, 2014
Examination of abdominal subcutaneous fat aspirates is a practical, sensitive and specific method for the diagnosis of systemic amyloidosis. Here we describe the development and implementation of a clinical assay using mass spectrometry-based proteomics ...
Julie A. Vrana, Jason D. Theis, Surendra Dasari, Oana M. Mereuta, Angela Dispenzieri, Steven R. Zeldenrust, Morie A. Gertz, Paul J. Kurtin, Karen L. Grogg, Ahmet Dogan   +9 more
doaj   +1 more source

A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Our prior work demonstrated systemic P301L‐tau injections in mice with mature amyloid resulted in several‐fold enhancement of tauopathy compared to non‐transgenic (NTg) littermates. METHODS APP+PS1 mice were injected intravenously with AAV.CAP‐B10 expressing P301L tau (A/P+P301L).
Dylan J. Finneran, Taylor Desjarlais, Brianna M. Jackman, David Morgan, Marcia N. Gordon   +4 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Cystic Lung Changes in Inclusion Body Myositis: An Unusual Pulmonary Manifestation

Respirology Case Reports, Volume 14, Issue 10, October 2026.
This report highlights a rare case of inclusion body myositis presenting with pulmonary disease. ABSTRACT Idiopathic inflammatory myopathies (IIMs) are chronic autoimmune disorders affecting skeletal muscles, with pulmonary involvement in 30%–40% of cases. Inclusion body myositis (IBM) is a distinct subset that usually does not involve the lungs.
Gehad Othman, Thasniya Ummer, Heshani De Silva, Harshana Bandara, Hector Chinoy   +4 more
wiley   +1 more source

Localized Tracheobronchial Transthyretin Amyloidosis Diagnosed After Hemoptysis: A Case Report

Respirology Case Reports, Volume 14, Issue 10, October 2026.
Pulmonary involvement in transthyretin amyloidosis (ATTR) is rare, and tracheobronchial involvement is particularly uncommon. We report localized wild‐type ATTR presenting with hemoptysis and diagnosed by bronchoscopic biopsy showing Congo red‐positive transthyretin deposition. ABSTRACT Pulmonary involvement in transthyretin amyloidosis (ATTR) is rare,
Koichi Inoue, Yasumasa Tanaka, Masahiro Yanagi, Haruhiko Michimata, Yuta Nagahisa, Shun Kondoh   +5 more
wiley   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Early‐Onset Wild‐Type Transthyretin Amyloidosis Polyneuropathy

Muscle &Nerve, Volume 74, Issue 5, Page 1471-1475, November 2026.
Chafic Karam, Kaylee Baker, Sami Khella, Brian Drachman, Pranav Chandrashekar, MacLean Nasrallah, Shunsuke Koga, Janice Pieretti   +7 more
wiley   +1 more source

Bilateral atrial appendage thrombosis in light chain cardiac amyloidosis: a case report

Frontiers in Cardiovascular Medicine
Light chain cardiac amyloidosis (AL-CA) is a severe and progressively infiltrative disease caused by the deposition of misfolded monoclonal immunoglobulin light chains in the myocardial extracellular space.
Haiyan Jia, Shengqi Jia, Weifeng Zhang, Zepeng Ma, Xiaomin Meng   +4 more
doaj   +1 more source

Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis

Case Reports in Nephrology, 2012
AL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain. Heavy proteinuria is one of its cardinal manifestations.
Yijuan Sun, Amarpreet Sandhu, Darlene Gabaldon, Jonathan Danaraj, Karen S. Servilla, Antonios H. Tzamaloukas   +5 more
doaj   +1 more source