Results 81 to 90 of about 19,748 (182)

o‐Terphenyl‐Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
This study presents the synthesis and binding properties of a new family of o‐terphenyl‐based macrocycles, TP[n] (n = 2‐8). The trimer variant efficiently binds phenylalanine in water with a 10‐fold selectivity compared to other amino acids and aromatic neurotransmitters.
Swapnil Ghule, Sayan Sarkar, Maria Eugenia Pérez‐Ojeda Rodriguez, Mark Spector, Frank Hampel, Evgeny A. Kataev   +5 more
wiley   +1 more source

Systemic Light Chain Amyloidosis [PDF]

, 2018
AbstractSystemic light chain (AL) amyloidosis is a rare protein misfolding and deposition disorder. Clonal plasma cells or rarely B cells produce immunoglobulin light chains with the potential to misfold. Treatment is clone directed with the goal to achieve a complete or at least very good hematological remission.
Monique Minnema, Stefan Schönland
openaire   +1 more source

Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics

Haematologica, 2014
Examination of abdominal subcutaneous fat aspirates is a practical, sensitive and specific method for the diagnosis of systemic amyloidosis. Here we describe the development and implementation of a clinical assay using mass spectrometry-based proteomics ...
Julie A. Vrana, Jason D. Theis, Surendra Dasari, Oana M. Mereuta, Angela Dispenzieri, Steven R. Zeldenrust, Morie A. Gertz, Paul J. Kurtin, Karen L. Grogg, Ahmet Dogan   +9 more
doaj   +1 more source

Recent advances in understanding and treating immunoglobulin light chain amyloidosis [version 1; referees: 2 approved]

F1000Research, 2018
Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in proteotoxicity and organ dysfunction.
Talha Badar, Anita D'Souza, Parameswaran Hari   +2 more
doaj   +1 more source

Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis

Case Reports in Nephrology, 2012
AL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain. Heavy proteinuria is one of its cardinal manifestations.
Yijuan Sun, Amarpreet Sandhu, Darlene Gabaldon, Jonathan Danaraj, Karen S. Servilla, Antonios H. Tzamaloukas   +5 more
doaj   +1 more source

DUAL expectations in light chain amyloidosis [PDF]

eClinicalMedicine, 2020
Schonland S., Palladini G.
openaire   +4 more sources

Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis

Pharmaceuticals
Background/Objectives: Antibody light chains form amyloid fibrils that lead to progressive tissue damage in amyloid light chain (AL) amyloidosis. The properties of each patient’s unique light chain appear to determine its propensity to form amyloid.
Gareth J. Morgan, Zach Yung, Brian H. Spencer, Vaishali Sanchorawala, Tatiana Prokaeva   +4 more
doaj   +1 more source

Neurofilament Light Chain in Systemic Amyloidosis: A Systematic Review

International Journal of Molecular Sciences
Peripheral and autonomic neuropathy are common disease manifestations in systemic amyloidosis. Neurofilament light chain (NfL), a neuron-specific biomarker, is released into the blood and cerebrospinal fluid after neuronal damage. This systematic review provides an overview on the value of NfL in early detection of neuropathy, central nervous system ...
Milou Berends, Hans L. A. Nienhuis, David Adams, Chafic Karam, Marco Luigetti, Michael Polydefkis, Mary M. Reilly, Yoshiki Sekijima, Bouke P. C. Hazenberg   +8 more
openaire   +2 more sources

Treatment Options For Relapsed/refractory Systemic Light-Chain (AL) Amyloidosis: Current Perspectives

Journal of Blood Medicine, 2019
Shayna Sarosiek, Vaishali Sanchorawala Amyloidosis Center, Boston University School of Medicine and Boston Medical Center, Boston, MA, USACorrespondence: Shayna Sarosiek; Vaishali SanchorawalaAmyloidosis Center, Boston University School of Medicine and ...
Sarosiek S, Sanchorawala V
doaj  

Brazilian consensus recommendations on the diagnosis and treatment of light chain amyloidosis. [PDF]

Hematol Transfus Cell Ther
Garibaldi PMM, Souto Filho JTD, de Magalhães Filho RJP, Szor RS, Miguel CE, Crusoe E, Bueno CT, Queiroz T, Hungria V.   +8 more
europepmc   +1 more source