Results 91 to 100 of about 598,532 (267)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The I/T curve coefficient for evaluating changes in neuromuscular excitability after polarized light irradiation - a placebo-controlled randomized trial

, 2020
Jolanta Zwolińska
openalex   +1 more source

Dynamical Evolution, Light Curves, and Spectra of Spherical and Collimated Gamma‐Ray Burst Remnants [PDF]

, 1999
A. Panaitescu, Peter Mészáros, A. Panaitescu, Peter Mészáros   +3 more
openalex   +1 more source

Comprehensive power spectral density analysis of the Fermi-LAT gamma-ray light curves of selected blazars [PDF]

, 2021
Natalia Żywucka, Mariusz Tarnopolski, Volodymyr Marchenko, J. Pascual-Granado   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

REVISITING EVIDENCE OF CHAOS IN X-RAY LIGHT CURVES: THE CASE OF GRS 1915+105 [PDF]

, 2016
Manu Mannattil, Himanshu Gupta, Sagar Chakraborty   +2 more
openalex   +1 more source

Hitting a New Low: The Unique 28 h Cessation of Accretion in the TESS Light Curve of YY Dra (DO Dra) [PDF]

, 2022
Katherine Hill, Colin Littlefield, P. Garnavich, Simone Scaringi, Paula Szkody, Paul Mason, Mark Kennedy, A. W. Shaw, Ava E. Covington   +8 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Generalized Bertrand Curves of Non-Light-like Framed Curves in Lorentz–Minkowski 3-Space

Mathematics
In this paper, we define the generalized Bertrand curves of non-light-like framed curves in Lorentz–Minkowski 3-space; their study is essential for understanding many classical and modern physics problems.
Linlin Wu, Anjie Zhou, Kaixin Yao, Donghe Pei   +3 more
doaj   +1 more source

Q2237+0305 source structure and dimensions from light-curve simulation [PDF]

, 2007
V. G. Vakulik, R.E. Schild, G. V. Smirnov, V. N. Dudinov, V. S. Tsvetkova   +4 more
openalex   +1 more source