Results 121 to 130 of about 1,819,617 (345)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Modeling quasar variability through self-organizing map-based neural process [PDF]
Serbian Astronomical JournalConditional Neural Process (QNPy) has shown to be a good tool for modeling quasar light curves. However, given the complex nature of the source and hence the data represented by light curves, processing could be time-consuming.
Čvorović-Hajdinjak I.
doaj +1 more source
Near-Infrared Light Curves of the Black Hole Binary A0620-00
, 2001 We measured the near-infrared orbital light curve of the black hole binary A0620-00 in 1995 and 1996. The light curves show an asymmetric, double-humped modulation with extra emission in the peak at orbital phase 0.75.
Claret A. +9 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
UBVRIJKL light curves of classical Cepheids [PDF]
Photoelectric observations and light curves of UBVRIJKL system for classical Cepheid variable stars - tables and ...
Johnson, H. L., Wisniewski, W. Z.
core +1 more source
The light curves of soft X-ray transients [PDF]
, 1998 A. R. King, H. G. Ritter
openalex +1 more source
Light-curve inversion formalism
The Astrophysical Journal, 1991 A block matrix formalism is presented for the light-curve inversion task, which rigorously incorporates photometric data taken at different aspects and phase angles. With sufficently dense coverage of opposition and nonopposition light curves, the ill-posed nature of the light-curves inversion problem may be reduced.
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Very Early Light Curve of SN 2015F in NGC 2442: A Possible Detection of Shock-Heated Cooling Emission and Constraints on SN Ia Progenitor System [PDF]
, 2015 Myungshin Im +6 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source