Results 111 to 120 of about 6,151,952 (306)

Adaptation across consecutive night shifts at 71°N under Arctic summer daylight and winter darkness: Effects on alertness, sleepiness, and fatigue

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: This study aimed to investigate how alertness, sleepiness, and fatigue change across consecutive night compared to morning shifts among Arctic shift workers and whether these effects differ between seasons of midnight sun and polar night ...
Andreas N Holme, Line Victoria Moen, Mikael Sallinen, Kristian Bernhard Nilsen, Charlotte N Boccara, Andrew JK Phillips, Fred Haugen, Dagfinn Matre   +7 more
doaj   +1 more source

Detailed assessment of night shift work aspects and potential mediators of its health effects: the contribution of field studies

Frontiers in Public Health
Night shift work has been associated with adverse health outcomes, but inconsistencies in epidemiological findings reveal gaps in understanding the mechanisms involved.
Tara van der Grinten, Daniella van de Langenberg, Linda van Kerkhof, Barbara N. Harding, Barbara N. Harding, Barbara N. Harding, Anne Helene Garde, Caisa Laurell, Roel Vermeulen, Susan Peters, Jelle Vlaanderen   +10 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Temporal changes in artificial light exposure of marine turtle nesting areas

, 2014
Artificial light at night poses a significant threat to multiple taxa across the globe. In coastal regions, artificial lighting close to marine turtle nesting beaches is disruptive to their breeding success.
Limpus, Colin, Sharolyn Anderson, Hamann, Mark, Mark Hamann, Limpus, Col, Ruth L. Kamrowski, Col Limpus, Jones, Rhondda, Rhondda Jones, Kamrowski, Ruth L, Kamrowski, Ruth L., Anderson, Sharolyn   +11 more
core   +1 more source

Reversed effects of RU486 and anisomycin on memory retention of light exposure or corticosterone facilitation in the dark-incubated chicks

, 2001
Memory formation for a weak passive avoidance task in the dark-incubated chicks is facilitated by light exposure or corticosterone administration at optimally pre-hatch time points.
Sui, N, Chen, J, Kuang, PZ, Joyce, D, Hu, JF   +4 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

History of COVID-19 and Circadian Light Hygiene in Young Adults

Russian Open Medical Journal
Background — The COVID-19 pandemic disrupted sleep and circadian rhythms, but the specific effects of prior infection on the body’s response to light for circadian regulation remain unclear.
Denis G. Gubin, Julia V. Boldyreva, Liina A. Danilova, Sergey A. Kolomeichuk, Svetlana Solovieva, Larisa E. Alkhimova, Natalya V. Kuznetsova, Oliver Stefani, Dietmar Weinert, Germaine Cornelissen   +9 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source