Results 81 to 90 of about 6,151,952 (306)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Seasonal light exposure and eye growth variation in young adults [PDF]
, 2017 Purpose\ud \ud Seasonal variations in myopia progression/axial elongation have been documented in studies of pediatric populations, and seasonal differences in light exposure have been hypothesized to play a role in these variations.
Read, Scott A. +3 more
core
Circadian and homeostatic sleep regulation in humans : effects of age and monochromatic light [PDF]
, 2006 The first part of this thesis deals with age-related modifications in the circadian and homeostatic sleep regulation, whereas in the second part, the effects of an evening exposure to monochromatic light on subsequent sleep architecture and sleep ...
Münch, Mirjam
core +1 more source
Light-induced current in rP2X2.
, 2022 A-B, Data are from whole-cell patch-clamp recordings of transfected HEK cells, voltage-clamped to -60mV. A, 7μM ATP-induced (left) and 440nm light-activated current (right) in rP2X2 P329C after exposure to BMA. The blue bar over the right trace indicates
Stephan Kellenberger (5042927) +1 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source