Results 121 to 130 of about 218,117 (279)

Snapshot 3D tracking of insulin granules in live cells

, 2018
Rapid and accurate volumetric imaging remains a challenge, yet has the potential to enhance understanding of cell function. We developed and used a multifocal microscope (MFM) for 3D snapshot imaging to allow 3D tracking of insulin granules labeled with ...
Alan Selewa, Hannah Yi, Itay Gdor, Mark Hereld, Matthew Daddysman, Norbert Scherer, Theresa Haunold, Xiang Huang, Xiaolei Wang   +8 more
core   +1 more source

Artifact‐Minimizing Ultrathin Transparent Electrodes Fabricated via iCVD for In Vivo Optogenetic Stimulation and Neural Signal Monitoring of Primary Visual Cortex

Advanced Functional Materials, EarlyView.
We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun, Minju Kim, Chaesung Kim, Yunyoung Choi, In‐Yeop Baek, Younghak Cho, Gyeongyong Lee, Yerim Jang, Min‐Ho Nam, Wonryung Lee, Maesoon Im, Hyejeong Seong   +11 more
wiley   +1 more source

RESOLFT Light-sheet Microscopy

, 2015
The concept of RESOLFT was introduced to break the resolution limit in fluorescence microscopy, which is set by the physical phenomenon of diffraction. It enables the separation of fluorophores inside a focal volume by driving reversible optical transitions between two discernible states. The family of reversibly switchable fluorescent proteins (RSFPs)
openaire   +2 more sources

Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

eLife
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throughput manner ...
Won Yeong Park, Jieun Yun, Jinho Shin, Byung Ho Oh, Gilsuk Yoon, Seung-Mo Hong, Ki Hean Kim   +6 more
doaj   +1 more source

Mechanochromism of Glassy Polymers Enabled by a Loop‐Forming Supramolecular Mechanophore

Advanced Functional Materials, EarlyView.
The supramolecular mechanophore LOOP is covalently introduced into glassy polymers, capable of reporting force‐induced pre‐failure damage and local fracture events in polymer glasses. Under different mechanical deformation modes, including grinding, tensile stretching, and scratching, LOOP probes irreversible events in polymer glasses through a ...
Linlin Deng, Chantal Graafsma, Felix Meyenhofer, Iulia Scarlat, Luca Bertossi, Christoph Weder, Jess M. Clough   +6 more
wiley   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Light-sheet optimization for microscopy

SPIE Proceedings, 2016
Aberrations, scattering and absorption degrade the performance light-sheet fluorescence microscopes (LSFM). An adaptive optics system to correct for these artefacts and to optimize the light-sheet illumination is presented. This system allows a higher axial resolution to be recovered over the field-of-view of the detection objective.
Dean Wilding, Paolo Pozzi, Oleg Soloviev, Gleb Vdovin, Michel Verhaegen   +4 more
openaire   +3 more sources

Mechanical properties of freely suspended atomically thin dielectric layers of mica

, 2012
We have studied the elastic deformation of freely suspended atomically thin sheets of muscovite mica, a widely used electrical insulator in its bulk form.
A. Castellanos-Gomez, A. Castellanos-Gomez, A. Castellanos-Gomez, A. Castellanos-Gomez, A. N. Rudenko, A. Splendiani, A. Turchanin, Albert Amor-Amorós, Andres Castellanos-Gomez, B. Radisavljevic, C. Gómez-Navarro, C. H. Lui, C. Lee, C. R. Dean, D. A. Kunz, D. Pacile, G. Eda, G. H. Lee, G. Lippert, G. Zhang, Gabino Rubio-Bollinger, Gary A. Steele, Herre S. J. van der Zant, J. Fan, J. Gao, J. Moser, K. F. Mak, K. Kim, K. S. Novoselov, K. Tapily, L. A. Ponomarenko, L. D. Landau, L. E. McNeil, L. Song, M. A. Meitl, M. Ishigami, M. Moreno-Moreno, M. Poot, M. W. Möller, Menno Poot, Nicolás Agraït, P. Blake, P. Nemes-Incze, R. V. Gorbachev, S. Gao, S. Kim, S. Miyake, S. Timoshenko, T. Korn, W. N. Sharpe, X. F. Lu, X. Li, Y. He, Y.-T. Fu   +53 more
core   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Structure Formation in Butterfly Scales: Interplay of Genetic Control, Mechanical Instabilities, and Dynamic Material Properties

Advanced Functional Materials, EarlyView.
Butterfly wing scales are intricate cuticular functional nanosctructures. This perspective suggests that spatially varying material properties, cytoskeletal constraints, and growth‐driven mechanical instabilities shape the resulting nanoscale architectures created from single cells.
Anupama Prakash, Victoria Lloyd, Yi Yang, Anna‐Lee Jessop, Anthony McDougal, Primož Pirih, Guillaume Duclos, Andrew Parnell, Mathias Kolle, Nicola J. Nadeau, Bodo D. Wilts   +10 more
wiley   +1 more source