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Nat Rev Methods Primers, 2021 Tissue clearing of gross anatomical samples was first described over a century ago and has only recently found widespread use in the field of microscopy. This renaissance has been driven by the application of modern knowledge of optical physics and chemical engineering to the development of robust and reproducible clearing techniques, the arrival of ...
Richardson DS +7 more
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T-CLEARE: a pilot community-driven tissue clearing protocol repository [PDF]
Frontiers in Bioengineering and BiotechnologySelecting and implementing a tissue clearing protocol is challenging. Established more than 100 years ago, tissue clearing is still a rapidly evolving field of research.
Kurt R. Weiss +13 more
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Rat perivascular adipose tissue microvasculature revealed by tissue clearing [PDF]
Frontiers in PhysiologyPerivascular adipose tissue (PVAT) surrounds the majority of blood vessels and plays diverse roles in vascular and metabolic functions. The hormonal and lipid exchange functions of PVAT require access to blood vessels.
Stephanie W. Watts +3 more
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Optimization of the optical transparency of bones by PACT-based passive tissue clearing [PDF]
Experimental and Molecular Medicine, 2023 Recent developments in tissue clearing methods such as the passive clearing technique (PACT) have allowed three-dimensional analysis of biological structures in whole, intact tissues, thereby providing a greater understanding of spatial relationships and
Byung-Ho Jin +9 more
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Method for tissue clearing: temporal tissue optical clearing. [PDF]
Biomed Opt Express, 2022 Light absorption and scattering in biological tissue are significant variables in optical imaging technologies and regulating them enhances optical imaging quality. Optical clearing methods can decrease light scattering and improve optical imaging quality to some extent but owing to their limited efficacy and the potential influence of optical clearing
Shariati B K B +5 more
europepmc +3 more sources
Compatibility of fast tissue clearing with targeted fluorescence imaging and pathology analysis using clinical head and neck cancer biopsies [PDF]
Scientific ReportsComplete tumor removal is crucial for successful surgical oncological outcomes. Targeted fluorescence imaging facilitates differentiation between healthy and cancerous tissue, enabling intraoperative margin assessment.
Ali Fakhrolmobasheri +7 more
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Advances in Optical Tissue Clearing for Three-Dimensional Ocular Imaging and Analysis [PDF]
Journal of OphthalmologyThe visualization of tissue architecture has long been constrained by optical absorption and scattering phenomena. Recent advances in optical tissue clearing techniques have revolutionized deep tissue imaging by overcoming these fundamental limitations ...
Shuhuai Meng +6 more
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A guidebook for DISCO tissue clearing
Molecular Systems Biology, 2021 Histological analysis of biological tissues by mechanical sectioning is significantly time‐consuming and error‐prone due to loss of important information during sample slicing.
Muge Molbay +4 more
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Aqueous-based tissue clearing in crustaceans [PDF]
Zoological Letters, 2018 Background Investigation of the internal tissues and organs of a macroscopic organism usually requires destructive processes, such as dissection or sectioning. These processes are inevitably associated with the loss of some spatial information. Recently,
Alu Konno, Shigetoshi Okazaki
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3D visualization of uterus and ovary: tissue clearing techniques and biomedical applications [PDF]
Frontiers in Bioengineering and BiotechnologyRecent advancements in tissue clearing and three-dimensional (3D) visualization technologies have enabled subcellular-level examination of entire organs, particularly in complex structures such as the ovary and uterus. Traditional histological approaches
Qiqi Liu +6 more
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