Results 91 to 100 of about 26,355 (196)

UPLC‐Q‐TOF‐MS/MS Profiling and Synergistic Anti‐HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC‐MSC‐Exos

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Human‐umbilical‐cord‐mesenchymal‐stem‐cell‐derived exosomes amplify anti‐hepatocellular‐carcinoma effects of gallic acid from Compound Muji Granules. This work identifies absorbed herbal constituents and reveals modulation of IL‐17/MAPK/p53 signaling in HCC organoid models, offering mechanistic insights for exosome‐assisted traditional‐medicine ...
Qiang Zhang   +12 more
wiley   +1 more source

Modification of spruce lignans with Trametes hirsuta laccase

open access: yes, 2002
The effect of Trametes hirsuta laccase on isolated spruce wood lignans was evaluated. Lignans were isolated from the heartwood of spruce branches and treated with different laccase dosages and treatment times. The effect of the treatment was monitored by
Tamminen, Tarja   +4 more
core   +1 more source

The Blood-Brain Barrier Permeability of Lignans and Malabaricones from the Seeds of Myristica fragrans in the MDCK-pHaMDR Cell Monolayer Model

open access: yesMolecules, 2016
The blood-brain barrier (BBB) permeability of twelve lignans and three phenolic malabaricones from the seeds of Myristica fragrans (nutmeg) were studied with the MDCK-pHaMDR cell monolayer model.
Ni Wu   +5 more
doaj   +1 more source

Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Polyphenol‐rich plant extracts provide natural immunomodulatory protection for oral health through complementary antioxidant, antibacterial, and anti‐inflammatory actions. Their potential to reduce harmful microbial activity and inflammation highlights the promise of dietary polyphenols as a natural strategy for maintaining oral health and preventing ...
Deepa Subramanian   +3 more
wiley   +1 more source

Valorization of Hot Trub: Extraction and Nanoparticle Encapsulation for Antitumor Applications

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Hot trub, a brewing by‐product, is valorized through optimized extraction of phenolic compounds and encapsulation in zein nanoparticles. The polyphenol‐rich extract shows antioxidant and photoprotective activity (SPF 13.84), while zein‐based nanocarriers, particularly chitosan‐ and caseinate‐coated variants, extend its effect on MCF‐7 breast cancer ...
Lilian Tatiani Dusman Tonin   +10 more
wiley   +1 more source

Preparative Isolation and Purification of Lignans from Justicia procumbens Using High-Speed Counter-Current Chromatography in Stepwise Elution Mode

open access: yesMolecules, 2015
Lignans, which are recognized as main constituents in Justicia procumbens, have attracted considerable attention due to their pharmacological activities, including antitumor, anti-hepatitic, cytotoxic, anti-microbial, and anti-virus properties ...
Peijuan Zhou   +8 more
doaj   +1 more source

Sesame Immunotherapy: A Systematic Review and Narrative Synthesis

open access: yesClinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Sesame allergy is associated with severe allergic reactions, low rates of spontaneous resolution, and significant psychosocial burden. Current management relies on strict avoidance and emergency treatment. Allergen‐specific immunotherapy, particularly oral immunotherapy (OIT), has emerged as a potential disease‐modifying approach, but evidence
Joanna Zielińska   +4 more
wiley   +1 more source

Lignans from Mosla scabra

open access: yes, 2000
Two new cyclobutane-type lignans, named moslolignans A and B, together with two known ones, andamanicin and magnosalin, were isolated from the whole plant of Mosla scabra.
Andrew Marston   +9 more
core   +1 more source

A New Triterpenoid from Teucrium viscidum

open access: yesMolecules, 2013
A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and
Yonghui Zhang   +7 more
doaj   +1 more source

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley   +1 more source

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