Results 131 to 140 of about 38,309 (309)
Metaphysics, 2012 "Eikon" (Greek word) or "Imago" (Latin word) signifies a kind of similarity or "likeness". In Plato’s philosophy, this term implies "likeness" of appearance to pattern or symbol.
m Piravivanak
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Evaluating Human Perception of Autonomous System Teammate-likeness
, 2021 The paper presents preliminary results on an evaluation of the perception of teammate-likeness in Human-Autonomy Teaming (HAT). Increases in an autonomous system’s core teaming skills could increase human perception of the teammate-likeness of an ...
Dorneich, Michael, Tokadli, Guliz
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Likeness Regress: Plato's Parmenides 132cl2-133a7
, 2003 Since Forms and particulars are separate, Plato is left with the task of describing the way in which they are related. One possible way of construing this relation is to suppose that particulars resemble Forms.
Otto, Karl Darcy
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Quadruped Robots and Canine Likeness: The Uncanny Valley Effect
This paper presents canine likeness features in robotic quadrupeds that influence their social perception. We adopted Contrastive Language-Image Pre-Training (CLIP), a neural network that has demonstrated signatures of the Uncanny Valley effect, to ...
Hung, Patrick C.K. +4 more
core +1 more source