Results 71 to 80 of about 5,522,817 (294)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Nash and Limit Equilibria of Games with a Continuum of Players [PDF]

We show that a strategy is a Nash equilibrium in a game with a continuum of players if and only if there exists a sequence of finite games such that its restriction is an "n-equilibria, with "n converging to zero. In our characterization, the sequence of
Carmona, Guilherme
core   +3 more sources

Reclassification of thermal equilibrium phase-transitions in thermodynamic limit systems

Scientific Reports
For relaxor-ferroelectrics and relaxor-ferromagnets, the initial Ehrenfest-classification gives no phase-transition that contradicts the measured order-parameter, while the classification according to order-parameter and its derivatives raises the ...
Lai Wei, Li-Li Zhang, Yi-Neng Huang
doaj   +1 more source

Mesoscopic superconductors in the London limit: equilibrium properties and metastability

, 2000
We present a study of the behaviour of metastable vortex states in mesoscopic superconductors. Our analysis relies on the London limit within which it is possible to derive closed analytical expressions for the magnetic field and the Gibbs free energy ...
A. Buzdin, A.I. Buzdin, A.K. Geim, A.K. Geim, A.K. Geim, A.L. Fetter, C. Bolech, C. Heinzel, C.P. Bean, D. M. Gangardt, E. Akkermans, E. Akkermans, E. Akkermans, E.B. Bogomol’nyi, G. Böbel, J. Pearl, J.J. Palacios, K. Mallick, M. Abramowitz, M. Morse, P. Singha Deo, P.A. Venegas, P.G. de Gennes, R. Benoist, V.A. Schweigert, V.A. Schweigert, V.A. Schweigert   +26 more
core   +1 more source

On the Out of Equilibrium Relaxation of the Sherrington - Kirkpatrick model [PDF]

, 1993
We derive analytical results for the large-time relaxation of the Sherrington - Kirkpatrick model in the thermodynamic limit, starting from a random configuration.
, , Bouchaud J P, Bray A J, Crisanti A, Cugliandolo L F, Dotsenko V, Franz S, Franz S, Freixa-Pascual M, Ginzburg S L, Hazewinkel M, Hoffmann K H, Horner H, J Kurchan, Koper G J, Kurchan J, L F Cugliandolo, Marinari E, Mézard M, Parisi G, Parisi G, Parisi G, Parisi G, Rieger H, Rossel C, Sompolinsky H, Struik L C E, Vincent E   +28 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Squeezed thermal reservoirs as a resource for a nano-mechanical engine beyond the Carnot limit

, 2017
The efficient conversion of thermal energy to mechanical work by a heat engine is an ongoing technological challenge. Since the pioneering work of Carnot, it is known that the efficiency of heat engines is bounded by a fundamental upper limit, the Carnot
Faelt, Stefan, Imamoglu, Atac, Klaers, Jan, Togan, Emre   +3 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Probabilistic Slope Stability Analysis: A Case Study

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Probabilistic slope stabilityanalyses are becoming more and more popular to evaluate the safety level ofslopes and the associated risk and reliability, especially in the recent years.Probabilistic approach can take into account the uncertainties and ...
Nejan Huvaj, Emir Ahmet Oğuz
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source