Results 41 to 50 of about 8,237 (245)

P53 tumor suppressor is required for efficient execution of the death program following treatment with a cytotoxic limonoid obtained from Melia azedarach [PDF]

, 2017
This work examines the antitumor activity of an isomeric mixture (1), composed of the limonoids meliartenin and its interchangeable isomer 12-hydroxyamoorastatin.
Bocco, Jose Luis, Carpinella, Maria Cecilia, Crespo, Maria Ines, González, María Laura, Joray, Mariana Belén, Laiolo, Jerónimo, Palacios, Sara Maria, Soria, Ramiro Gaston, Villafañez, Florencia   +8 more
core   +1 more source

Busca de inibidores da enzima glicossomal gliceraldeído 3-fosfato desidrogenase de Trypanosoma cruzi [PDF]

, 2009
The inhibitory activity of crude extracts of Meliaceae and Rutaceae plants on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) enzyme from Trypanosoma cruzi was evaluated at 100 μg/mL.
AMBROZIN, Alessandra R. P., CASTILHO, Marcelo S., FERNANDES, João B., LEITE, Ana C., LIMA, M. Inês S., OLIVA, Glaucius, PIRANI, José R., SILVA, Maria Fátima das G. F. da, THIEMANN, Otavio Henrique, VIEIRA, Paulo C.   +9 more
core   +1 more source

Accurate Identification of Bioactive Meliaceae Limonoids by UHPLC–MS/MS Based Structure–Fragment Relationships (SFRs)

ACS Omega, 2021
Limonoids are bioactive plant specialized metabolites found in the Meliaceae family. The basic limonoids, i.e., azadiradione, epoxyazadiradione, and gedunin have been exploited for various bioactivities and therefore are the potential drug leads for ...
F. Mulani, Sharvani S. Nandikol, S. Haldar, H. Thulasiram   +3 more
semanticscholar   +1 more source

Bitterness and antibacterial activities of constituents from Evodia rutaecarpa

BMC Complementary and Alternative Medicine, 2017
Background Bitter herbs are important in Traditional Chinese Medicine and the Electronic Tongue (e-Tongue) is an instrument that can be trained to evaluate bitterness of bitter herbs and their constituents.
Xiaoguang Liang, Bo Li, Fei Wu, Tingzhao Li, Youjie Wang, Qiang Ma, Shuang Liang   +6 more
doaj   +1 more source

Impact of repeated NeemAzal®-treated blood meals on the fitness of Anopheles stephensi mosquitoes [PDF]

, 2015
Background: Herbal remedies are widely used in many malaria endemic countries to treat patients, in particular in the absence of anti-malarial drugs and in some settings to prevent the disease.
ABAY, SOLOMON MEQUANENTE, DAHIYA, NISHA RANI, Edson G. Dembo1, George K. Christophides, Giuseppina Chianese, HABLUETZEL, Annette, Johnbull S. Ogboi, LUCANTONI, LEONARDO, LUPIDI, Giulio   +8 more
core   +5 more sources

Carapanolides T–X from Carapa guianensis (Andiroba) Seeds

Molecules, 2015
Two new mexicanolide-type limonoids, carapanolides T–U (1–2), and three new phragmalin-type limonoids, carapanolides V–X (3–5), were isolated from the seeds of Carapa guianensis (andiroba).
Teppei Miyake, Sari Ishimoto, Naoko Ishimatsu, Keiichiro Higuchi, Katsuhiko Minoura, Takashi Kikuchi, Takeshi Yamada, Osamu Muraoka, Reiko Tanaka   +8 more
doaj   +1 more source

Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension

BMC Plant Biology, 2018
Background Neem tree serves as a cornucopia for triterpenoids called limonoids that are of profound interest to humans due to their diverse biological activities.
Thiagarayaselvam Aarthy, Fayaj A. Mulani, Avinash Pandreka, Ashish Kumar, Sharvani S. Nandikol, Saikat Haldar, Hirekodathakallu V. Thulasiram   +6 more
doaj   +1 more source

Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Frontiers in Pharmacology, 2017
Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been ...
Arnaud F. Kouam, Arnaud F. Kouam, Fei Yuan, Frédéric N. Njayou, Hongtao He, Roméo F. Tsayem, Babayemi O. Oladejo, Fuhang Song, Paul F. Moundipa, George F. Gao   +9 more
doaj   +1 more source

Effects of Azadirachta indica seed kernel extracts on early erythrocytic schizogony of Plasmodium berghei and pro-inflammatory response in inbred mice [PDF]

, 2019
Background: Medicinal plant research may contribute to develop new pharmacological control tools for vector borne diseases, such as malaria. Methods: The effects of methanol extracts (ME) obtained from seed kernel of ripe and unripe Azadirachta indica ...
Bruschi, F., Chianese, G., Esposito, F., Habluetzel, A., Lopatriello, A., Nkouangang, J., Pinto, B., Saviozzi, M., Taglialatela Scafati, O., Tapanelli, S., Tenoh, A. R., Yerbanga, R. S.   +11 more
core   +2 more sources

Meliacarpinin-Type Limonoids from the Bark of Melia toosendan

Molecules, 2018
Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan.
Yalin Hu, Li Heng, Rong Xu, Junhe Li, Shanshan Wei, Deran Xu, Jun Luo, Yi Li   +7 more
doaj   +1 more source