Results 111 to 120 of about 4,881,979 (331)

The Scale Model Room Approach to Test the Performance of Airtight Membranes to Control Indoor Radon Levels and Radiation Exposure

Atmosphere
Indoor radon is one of the most significant contributors to lung cancer after smoking. Mitigation strategies based on protecting buildings with radon barrier materials, combined with home ventilation or room pressurization, are regularly used.
Manuela Portaro, Ilaria Rocchetti, Paola Tuccimei, Gianfranco Galli, Michele Soligo, Cristina Longoni, Dino Vasquez   +6 more
doaj   +1 more source

Enhanced Anticancer Potency of Hydroxytyrosol and Curcumin by PLGA-PAA Nano-Encapsulation on PANC-1 Pancreatic Cancer Cell Line [PDF]

, 2020
Mahdieh Farhoudi, Behrouz Shadman, Reza Chavoshi, Nasrin Seyyedsani, Elnaz Aghaei, Elham Taheri, Pouya Goleij, Saba Hajazimian, Vahidreza Karamad, Alireza Isazadeh, Behzad Baradaran   +10 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Assessing the Effect of Insulation Materials Used for Energy Conservation in Buildings on Indoor Radon—The Scale Model Room Approach

Applied Sciences
This study investigates how external insulation materials used for energy efficiency affect indoor radon accumulation, using a scale model room built with ignimbrite, a highly radon-emitting volcanic rock. Two insulation materials—mineral wool (open-cell,
Ilaria Rocchetti, Manuela Portaro, Paola Tuccimei, Gianfranco Galli, Michele Soligo, Cristina Longoni, Dino Vasquez   +6 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Field Monitoring and Numerical Simulation of Spatiotemporal Effects During Deep Excavation in Mucky Soft Soil: A Case Study

Applied Sciences
The issue of geotechnical hazards induced by excavation in soft soil areas has become increasingly prominent. However, the retaining structure and surface settlement deformation induced by the creep of soft soil and spatial effect of the excavation ...
Qiang Wu, Jianxiu Wang, Yanxia Long, Xuezeng Liu, Guanhong Long, Shuang Ding, Li Zhou, Huboqiang Li, Muhammad Akmal Hakim bin Hishammuddin   +8 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

New Cameron-Liebler line classes with parameter $\frac{q^2+1}{2}$ [PDF]

, 2017
Antonio Cossidente, Francesco Pavese
openalex   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source