Results 81 to 90 of about 4,881,979 (331)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Mixing state of oxalic acid containing particles in the rural area of Pearl River Delta, China: implications for the formation mechanism of oxalic acid [PDF]

Atmospheric Chemistry and Physics, 2017
The formation of oxalic acid and its mixing state in atmospheric particulate matter (PM) were studied using a single-particle aerosol mass spectrometer (SPAMS) in the summer and winter of 2014 in Heshan, a supersite in the rural area of the Pearl ...
C. Cheng, C. Cheng, M. Li, M. Li, C. K. Chan, H. Tong, C. Chen, D. Chen, D. Wu, D. Wu, L. Li, L. Li, C. Wu, C. Wu, P. Cheng, P. Cheng, W. Gao, W. Gao, Z. Huang, Z. Huang, X. Li, X. Li, Z. Zhang, Z. Zhang, Z. Fu, Y. Bi, Z. Zhou, Z. Zhou   +27 more
doaj   +1 more source

LINE-1 Retrotransposition Activity in Human Genomes [PDF]

Cell, 2010
Highly active (i.e., "hot") long interspersed element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of hot L1s in the human population remains largely unexplored. Here, we used a fosmid-based, paired-end DNA sequencing strategy to identify 68 full-length L1s that are ...
Beck, CR, Collier, P, Macfarlane, C, Malig, M, Kidd, JM, Eichler, EE, Badge, RM, Moran, JV   +7 more
openaire   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci [PDF]

, 2012
LINE-1 repeats account for ∼17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted.
El Maarri, Osman, Meesters, Christian, Nusgen, Nicole, Schreiner, Felix, Singer, Heike, Walier, Maja, Wienker, Thomas, Woelfe, Joachim   +7 more
core   +1 more source

APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition [PDF]

Journal of Biological Chemistry, 2006
The human cytidine deaminase family APOBEC3 represents a novel group of proteins in the field of innate defense mechanisms that has been shown to be active against a variety of retroviruses. Here we examined whether members of the APO-BEC3 family have an impact on retrotransposition of human long interspersed nuclear elements (LINE-1s or L1s).
Heide, Muckenfuss, Matthias, Hamdorf, Ulrike, Held, Mario, Perković, Johannes, Löwer, Klaus, Cichutek, Egbert, Flory, Gerald G, Schumann, Carsten, Münk   +8 more
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

An intronic LINE-1 regulates IFNAR1 expression in human immune cells

Mobile DNA, 2023
Background Despite their origins as selfish parasitic sequences, some transposons in the human genome have been co-opted to serve as regulatory elements, contributing to the evolution of transcriptional networks.
Carmen A. Buttler, Daniel Ramirez, Robin D. Dowell, Edward B. Chuong   +3 more
doaj   +1 more source

The MOV10 Helicase Inhibits LINE-1 Mobility [PDF]

Journal of Biological Chemistry, 2013
LINE-1 (long interspersed element 1) is an autonomous non-long terminal repeat retrotransposon. Its replication often causes mutation and rearrangement of host genomic DNA. Accordingly, host cells have evolved mechanisms to control LINE-1 mobility. Here, we report that a helicase named MOV10 effectively suppresses LINE-1 transposition.
Xiaoyu, Li, Jianyong, Zhang, Rui, Jia, Vicky, Cheng, Xin, Xu, Wentao, Qiao, Fei, Guo, Chen, Liang, Shan, Cen   +8 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source