Results 101 to 110 of about 6,905,915 (330)
Italian National Conference on Sensors, 2018 With the growth of the national economy, there is increasing demand for electricity, which forces transmission line corridors to become structurally complicated and extend to complex environments (e.g., mountains, forests).
Xinyan Qin +5 more
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Reciprocal relativity of noninertial frames and the quaplectic group
, 2005 Newtonian mechanics has the concept of an absolute inertial rest frame. Special relativity eliminates the absolute rest frame but continues to require the absolute inertial frame.
E. Wigner +5 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Bulk and surface symmetry energy for the nuclei far from the valley of stability [PDF]
Ядерна фізика та енергетика, 2007 The direct variational method have been applied to the calculation of the symmetry energy for medium and heavy nuclei. The functional of energy of the Thomas - Fermi approximation with the effective Skyrme forces have been used.
V. M. Kolomietz, A. I. Sanzhur
doaj
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
When contact lines remember: Surface charge and the evolving interaction with defects
DropletThe motion of contact line plays a crucial role in both natural phenomena and industrial processes. While it is well known that surface defects influence contact line dynamics, we demonstrate that their impact depends not only on geometry, size, and ...
Yaolei Xiang +4 more
doaj +1 more source