Results 121 to 130 of about 2,548,043 (302)
Profiles of thermal line emission from advection dominated accretion flows
, 2000 Recently, Narayan & Raymond (1999) proposed that the thermal emission lines from the hot plasma in advection dominated accretion flows (ADAFs) are potentially observable with the next generation of X-ray observatories, with which the physical properties ...
Cao, Xinwu, Xu, Y. D., You, J. H.
core
Line profile and continuum variability in the very broad-line Seyfert galaxy Mrk 926
, 2010 We present results of an intensive spectroscopic variability campaign of the very broad-line Seyfert 1 galaxy Mrk 926. Our aim is to investigate the broad-line region (BLR) by studying the intensity and line profile variations of this galaxy on short ...
Bentz +49 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Profile line accuracy in cephalometric radiographs
American Journal of Orthodontics and Dentofacial OrthopedicsIntroduction This study investigates the accuracy of facial soft-tissue profile lines in lateral cephalometric radiographs by comparing them to true profile lines derived from 3-dimensional photographs.Methods This prospective methodological study was performed on preexisting records of 100 orthodontic patients.
Marie-Laure Arn +4 more
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Line cascade of turbine profiles
RUDN Journal of Engineering Research, 2010 An article presents a new method for designing the Line Cascade of turbine profiles.
L V Vinogradov
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source